Gene Expression and Endothelial Cell Differentiation

  • D. S. Grant
  • J. L. Kinsella
  • H. K. Kleinman
Part of the NATO ASI Series book series (NSSA, volume 285)

Abstract

Regulation of the vascular wall is an essential process that allows normal blood flow and facilitates the exchange of soluble gases, ions and vital macromolecules. Normally all vessels are composed of a nonthrombogenic layer of endothelial cells which line the intimai surface of the vessel walls. The differentiation state of this cell layer is maintained by components (factors) present in the blood the extravascular stroma and the extracellular matrix. The contribution of the matrix to vascular wall homeostasis has been unclear in the past, even though matrix comprise a significant portion of the vasculature. In fact, the endothelium is adherent to a thin, specialized extracellular layer know as a basement membrane. The basement membrane provides not only support and an adhesive surface for the endothelium but also maintains the normal differentiated phenotype of the cell layer. Vessel walls also are comprised of other vascular cells such a smooth muscle cells, pericytes and fibroblasts. The former two also have their own basement membrane, and the latter is surrounded by a collagenous insterstitium (the adventitia) and in some cases elastic fibers. Studies which examine the cells comprising the vessel walls must also evaluate the role of the matrix in the maintenance of its structure as well.

Keywords

Migration Hepatitis Heparin Sarcoma Polypeptide 

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • D. S. Grant
    • 1
  • J. L. Kinsella
    • 2
  • H. K. Kleinman
    • 3
  1. 1.Department of Medicine, Cardeza Foundation for Hematological ResearchThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Lab of Developmental BiologyNational Institute of Dental Research, NIHBethesdaUSA
  3. 3.National Institute on Aging, NIABaltimoreUSA

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