Abstract
Angiogenesis, a critical component of tissue repair, leads to increased oxygenation and endothelial permeability. This improves tissue energetics, enhances the effect of recruited cytokines, and improves protein transport to and from the wound site. We propose metabolic conditions in the wound mediate much of the cellular and cytokine response. We will describe this milieu and further introduce a novel metabolic regulatory mechanism capable of sensing the redox state of tissues and mediating the response. This system acts through Adenosine diphospho ribosylation (ADPR) which mediates hypoxic and lactate induction of critical metabolic events in wound repair including angiogenesis. This is specifically relevant to wound angiogenesis because conditions of hypoxia and elevated lactate coexist in wounds.
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© 1996 Plenum Press, New York
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Constant, J.S., Suh, D.Y., Hussain, M.Z., Hunt, T.K. (1996). Wound Healing Angiogenesis: The Metabolic Basis of Repair. In: Maragoudakis, M.E. (eds) Molecular, Cellular, and Clinical Aspects of Angiogenesis. NATO ASI Series, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0389-3_14
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DOI: https://doi.org/10.1007/978-1-4613-0389-3_14
Publisher Name: Springer, Boston, MA
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