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Molecular, Cellular, and Clinical Aspects of Angiogenesis pp 125–139Cite as

Angiogenesis in the Female Reproductive Organs

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Part of the book series: NATO ASI Series ((NSSA,volume 285))

Abstract

Angiogenesis refers to the formation of new blood vessels, or neovascularization, and is an essential component of tissue growth and development (Folkman and Klagsbrun, 1987; Hudlicka, 1984; Klagsbrun and D’Amore, 1991; Shepro and D’Amore, 1984). The angiogenic process begins with capillary proliferation and culminates in the formation of a new microcirculatory bed, composed of arterioles, capillaries and venules (Folkman and Klagsbrun, 1987; Hudlicka, 1984; Klagsbrun and D’Amore, 1991; Shepro and D’Amore, 1984). The initial component of angiogenesis, capillary proliferation, has been shown to consist of at least three processes: 1) fragmentation of the basal lamina of the existing vessel, 2) migration of endothelial cells (the primary cell type comprising capillaries) from the existing vessel toward the angiogenic stimulus, and 3) proliferation of endothelial cells (Folkman and Klagsbrun, 1987; Klagsbrun and D’Amore, 1991; Shepro and D’Amore, 1984). Neovascularization is completed by formation of capillary lumina and differentiation of the newly formed capillaries into arterioles and venules (Hudlicka, 1984; Klagsbrun and D’Amore, 1991).

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References

  • Abel, M.H., 1985, Prostanoids and menstruation. In: Mechanisms of menstrual bleeding, edited by Baird, D.T., Michie, E.A., pp 139–156. Raven Press, New York.

    Google Scholar 

  • Adair, T.H., Gay, W.J., and Montani, J.-P., 1990, Growth regulation of the vascular system: evidence for a metabolic hypothesis. Am. J. Physiol. 259:R393-R404.

    PubMed  CAS  Google Scholar 

  • Andersen, D.H., 1926, Lymphatics and blood vessels of the ovary of the sow. Contrib. Embryol. 88:107–123.

    Google Scholar 

  • Assheton, R., 1906, Phil. Trans. Roy. Soc, London,, Ser. B. 198:143–200.

    Article  Google Scholar 

  • Baird, A., Esch, F., Mormede, P., Ueno, N., Ling, N., et al., 1986, Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues. Recent Prog. Horm. Res. 42:143–205.

    PubMed  CAS  Google Scholar 

  • Barcroft, J., 1947, Researches on Pre-Natal Life. Charles C. Thomas, Springfield, EL.

    Google Scholar 

  • Barleon, B., Hauser, S., Schollmann, C, Weindel, K., Marme, D., Yayon, A., and Weich, H.A., 1994, Differential expression of the two vegf receptors flt and kdr in placenta and vascular endothelial cells, J. Cell. Biochem. 54: 56–66.

    CAS  Google Scholar 

  • Baserga R. The Biology of Cell Reproduction. Harvard University Press, Cambridge; 1985.

    Google Scholar 

  • Bassett, D.L., 1943, The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle. Am. J. Anat. 73:251–291.

    Article  Google Scholar 

  • Beranek, J.T., 1988, Antiangiogenesis comes out of its shell. Cancer J. 2:87–88.

    Google Scholar 

  • Boshier, D.P., 1969, A histological and histochemical examination of implantation and early placentome formation in sheep. J. Reprod. Fert. 19:51–61.

    Article  CAS  Google Scholar 

  • Burgess, W.H., and Maciag, T., 1989, The heparin-binding, fibroblast, growth factor family of proteins. Annu. Rev. Biochem. 58:575–606.

    Article  PubMed  CAS  Google Scholar 

  • Burgos, H., Herd, A., and Bennett, J.P., 1989, Placental angiogenic and growth factors in the treatment of chronic varicose ulcers: preliminary communication. J Roy. Soc. Med. 82:598–99.

    PubMed  CAS  Google Scholar 

  • Catchpole HR. Hormonal mechanisms in pregnancy and parturition. In: Cupps PT, ed. Reproduction in Domestic Animals, 4th edn. Academic Press, New York; 1991:361–383.

    Google Scholar 

  • Charnock-Jones, D.S., Sharkey, A.M., Rajput-Williams, J., Burch, D., Schofield, J.P., Fountain, S.A., Boocock, CA., and Smith, S.K., 1993, Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines, Biol. Reprod. 48:1120–1128.

    Article  PubMed  CAS  Google Scholar 

  • Charnock-Jones, D.S., Sharkey, A.M., Boocock, CA., Ahmed, A., Plevin, R., Ferrara, N., and Smith, S.K., 1994, Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells, Biol. Reprod., 51: 524–530.

    Article  PubMed  CAS  Google Scholar 

  • Christenson, L.K., and Stouffer, R.L., 1995, Endothelial cell proliferation in the primate corpus luteum, FASEB J. 9: A543,Abstr. 3146,.

    Google Scholar 

  • Clark, J.G., 1900, The origin, development and degeneration of the blood vessels of the human ovary. John Hopkins Hosp. Rep. 9:593–676.

    Google Scholar 

  • Cullinan-Bove, K., and Koos, R.D., 1993, Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: Rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth, Endocrinology 133: 829–837.

    Article  PubMed  CAS  Google Scholar 

  • Denekamp, J., 1984, Vasculature as a target for tumour therapy. In: Progress in applied microcirculation, edited by Hammersen, F., Hudlicka, O,, Vol. 4, , pp 28–38. Karger, Basel.

    Google Scholar 

  • Dharmarajan, A.M., Bruce, N.W., and Meyer, G.T., 1985, Qualitative ultra- structural characteristics relating to transport between luteal cell cytoplasm and blood in the corpus luteum of the pregnant rat. Am. J. Anat. 172:87–99.

    Article  PubMed  CAS  Google Scholar 

  • DiZerega, G.S., and Hodgen, G.D., 1980, Fluorescence localization of luteinizing hormone/human chorionic gonadotropin uptake in the primate ovary. II. changing distribution during selection of the dominant follicle. J. Clin. Endocrinol. Metab. 51:903–907.

    Article  PubMed  CAS  Google Scholar 

  • Doraiswamy, V., A.T. Grazul-Bilska, W.A. Ricke, D.A. Redmer and L.P. Reynolds. 1995. Immunoneutralization of angiogenic activity from ovine corpora lutea, CL, with antibodies against fibroblast growth factor (FGF, -2 and vascular endothelial growth factor, VEGF,. Biol. Reprod. 52(Suppl. 1):112.

    Google Scholar 

  • Ebaugh, M.J., Singh, M., Brace, R.A., anc Cheung, C.Y., 1994, Vascular endothelial growth factor (VEGF) gene expression in ovine placenta and fetal membranes. Proc. 41st Annu. Mtg. Soc. Gynecol. Invest., Abstr. P198.

    Google Scholar 

  • Eckstein, P., and Zuckerman, S., 1952, Changes in the accessory reproductive organs of the non-pregnant female. In: Marshall’s physiology of reproduction, edited by Parker, A.S., 3rd ed., Vol. I, pp 543–654. Longman’s Green, NY.

    Google Scholar 

  • Edey, T.N., 1969, Prenatal mortality in sheep: a review. Anim. Breed. Abstr. 37:173–90.

    Google Scholar 

  • Ferenczy, A., Bertrand, and Gelfand, M.M., 1979, Proliferation kinetics of human endometrium during the normal menstrual cycle. Am. J. Obstet. Gynecol. 133:859–867.

    PubMed  CAS  Google Scholar 

  • Ferrara, N., 1993, Vascular endothelial growth factor, Trends Cardiovasc. Med. 3: 244–250.

    Article  PubMed  CAS  Google Scholar 

  • Ferrell, C.L., 1989, Placental regulation of fetal growth. In: Animal growth regulation, edited by Campion, D.R., Hausman, G.J., Martin, R.J., pp 1–19. Plenum, New York.

    Google Scholar 

  • Ferrell, C.L., 1991, Maternal and fetal influences on uterine and conceptus development in the cow: I. growth of tissues in the gravid uterus. J. Anim. Sci. 69:1945–53.

    PubMed  CAS  Google Scholar 

  • Ferriani, R.A., Charnock-Jones, D.S., Prentice, A., Thoman, E.J., and Smith, S.K., 1993, Imminohistochemical localization of acidic and basic fibroblast growth facotrs in normal human endometrium and endometriosis and the detection of their mRNA by polymerase chain reaction, Human Reprod. 8: 11–16.

    CAS  Google Scholar 

  • Findlay, J.K., 1986, Angiogenesis in reproductive tissues. J. Endocrinol. 111:357–366.

    Article  PubMed  CAS  Google Scholar 

  • Folkman, J., and Klagsbrun, M., 1987, Angiogenic factors. Science 233:442–447.

    Article  Google Scholar 

  • Fricke, P.M., 1991, Regulators of follicular growth and development in the cow, M.S. Thesis, North Dakota State University, Fargo, ND, USA.

    Google Scholar 

  • Gaede, S.D., Sholley, M.M., and Quattropani, S.L., 1985, Endothelial mitosis during the initial stages of corpus luteum neovascularization in the cycling adult rat. Am. J. Anat. 172:173–180.

    Article  PubMed  CAS  Google Scholar 

  • Garrido, C, Simon, S., and Gospodarowicz, D., 1993, Transcriptional regulation of vascular endothelial growth factor gene expression in ovarian granulosa cells, Growth Factors 8:109–117.

    Article  PubMed  CAS  Google Scholar 

  • Goodman RL. Neuroendocrine control of the ovine estrous cycle. In: Knobil E, Neil J, eds. The Physiology of Reproduction. Raven Press, New York 1988:1929–1969

    Google Scholar 

  • Gospodarowicz, D., and Thakral, K.K., 1978, Production of a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum. Proc. Natl. Acad. Sci. USA 75:847–851.

    Article  PubMed  CAS  Google Scholar 

  • Grazul-Bilska, A.T., Redmer, D.A., Killilea, S.D., Kraft, K.C., and Reynolds, L.P., 1992a, Production of mitogenic factor(s, by ovine corpora lutea throughout the estrous cycle. Endocrinology 130:3625–3632.

    Article  CAS  Google Scholar 

  • Grazul-Bilska, A.T., Reynolds, L.P., Slanger, W.D., and Redmer, D.A., 1992b, Production of heparin-binding angiogenic factor(s, by bovine corpora lutea during pregnancy. J. Anim. Sci. 70:254–262.

    CAS  Google Scholar 

  • Grazul-Bilska, A.T., D.A. Redmer, S.D. Killilea, J. Zheng and L.P. Reynolds, 1993, Initial characterization of endothelial mitogens produced by bovine corpora lutea from the estrous cycle. Biochem. Cell Biol. 71:270–277.

    Article  PubMed  CAS  Google Scholar 

  • Grazul-Bilska, A.T., Rechner, D.A., Killilea, S.D., and Reynolds, L.P., 1995, Characterization of mitogenic factors produced by ovine corpora lutea of early pregnancy, Growth Factors, In press,.

    Google Scholar 

  • Green, W.W., and Winters, L.M., 1945, Prenatal development of sheep. MN Agri. Exp. Sta. Tech. Bull. 169:1–36.

    Google Scholar 

  • Greenwald, G.S., 1989, Temporal and topographic changes in DNA synthesis after induced follicular atresia. Biol. Reprod. 41:175–181.

    Article  PubMed  CAS  Google Scholar 

  • Greenwald, G.S., and Terranova, P.F., 1988, Follicular selection and its control, edited by Knobil, E., Neill, J., et al., pp 387–445. Raven Press, New York.

    Google Scholar 

  • Greiss, F.C., and Anderson, S.G., 1970, Uterine blood flow during early ovine pregnancy. Am. J. Obstet. Gynecol. 106:30–38.

    PubMed  Google Scholar 

  • Grisham, J.W., 1962, A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; Autoradiography with thymidine-H3. Cancer Res. 22:842–849.

    PubMed  CAS  Google Scholar 

  • Hansel W, Concannon PW, Lukaszewska JH. Corpora lutea of the large domestic animals. Biol Reprod. 1973; 8:222–245.

    CAS  Google Scholar 

  • Heap RB, Flint APF. Pregnancy. In: Austin CR, Short RV, eds. Reproduction in Mammals, 2nd edn. Book 3: Hormonal Control of Reproduction. Cambridge University Press, Cambridge 1984:153–194.

    Google Scholar 

  • Hossain MI, Lee CS, Clarke IJ, O’Shea JD. Ovarian and luteal blood flow, and peripheral plasma progesterone levels, in cyclic guinea pigs. J Reprod Fertil. 1979; 57:167–174.

    Article  PubMed  CAS  Google Scholar 

  • Hudlicka, O., 1984, Development of microcirculation: capillary growth and adaptation. In: Handbook of Physiology, edited by Renkin, E.M., Michel, C.C.,, Sec. 2, Vol. IV, Part 1, , pp 165–216. Waverly Press, Baltimore.

    Google Scholar 

  • Jablonka-Shariff, A., A.T. Grazul-Bilska, D.A. Redmer and L.P. Reynolds. 1993. Growth and cellular proliferation of ovine corpora lutea throughout the estrous cycle. Endocrinology 133:1871–1879.

    Article  PubMed  CAS  Google Scholar 

  • Jablonka-Shariff, A., P.M. Fricke, A.T. Grazul-Bilska, L.P. Reynolds and D.A. Redmer. 1994. Size, number, cellular proliferation, and atresia of gonadotropin-induced follicles in ewes. Biol. Reprod. 51:531–540.

    Article  PubMed  CAS  Google Scholar 

  • Jackson, M.R., Carney, E.W., Lye, S.J., Ritchie, J.W.K., 1994, Localization of two angiogenic growth factors (PDECGF and VEGF, in human placentae throughout gestation. Placenta 15: 341–353.

    Article  PubMed  CAS  Google Scholar 

  • Jakob, W., Jentzsch, K.D., Mauersberger, B., and Oehme, P., 1977, Demonstration of angiogenesis-activity in the corpus luteum of cattle. Exp. Path. 13:231–236.

    CAS  Google Scholar 

  • Johnson, ML., Y. Ma and L.P. Reynolds. 1993. Influence of ovarian steroids on uterine growth in ewes. Biol. Reprod. 48, Suppl. 1,:162.

    Google Scholar 

  • Jones, G.S., Maffezzoli, R.D., Strott, CA., Ross, G.T., and Kaplan, G., 1970, Pathophysiology of reproductive failure after clomiphene-induced ovulation. Am. J. Obstet. Gynecol. 108:847–867.

    PubMed  CAS  Google Scholar 

  • Klagsbrun, M., and D’Amore, P.A., 1991, Regulators of angiogenesis. Annu. Rev. Physiol. 53:217–39.

    Article  PubMed  CAS  Google Scholar 

  • Klagsbrun, M., and Soker, S., 1993, Vegf/vpf — the angiogenesis factor found, Curr. Biol. 3: 699–702.

    Article  PubMed  CAS  Google Scholar 

  • Ko, Y., Young, L.C., Ott, T.L., Davis, M.A., Simmen, R.C.M., Bazer, F.W., and Simmen, F.A., 1991, Insulin-like growth factors in sheep uterine fluids: Concentrations and relationship to ovine trophoblast protein-1 production during early pregnancy. Biol. Reprod. 45:135–142.

    Article  PubMed  CAS  Google Scholar 

  • Koos, R.D., 1986, Stimulation of endothelial cell proliferation by rat granulosa cell-conditioned media. Endocrinology 119:481–489.

    Article  PubMed  CAS  Google Scholar 

  • Koos, R.D., 1995, Increased expression of vascular endothelial growth/permeability vactor in the rat ovary following an ovulatory gonadotropin stimulus: Potential roles in follicle rupture, Biol. Reprod. 52: 1426–1435.

    Article  PubMed  CAS  Google Scholar 

  • Koos, R.D., and LeMaire, W.J., 1983, Evidence for an angiogenic factor from rat follicles. In: Factors regulating ovarian function, edited by Greenwald, G.S., Terranova, P.F., pp 191–195. Raven Press, New York.

    Google Scholar 

  • Koos, R.D., and Olson, CE., 1989, Expression of basic fibroblast growth factor in the rat ovary: detection of mRNA using reverse transcription-polymerase chain reaction amplification. Molec. Endocrinol. 3:2041–2048.

    Article  CAS  Google Scholar 

  • Magness, R.R., Christenson, R.K., and Ford, S.P., 1983, Ovarian blood flow throughout the estrous cycle and early pregnancy in sows. Biol. Reprod. 28:1090–1096.

    Article  PubMed  CAS  Google Scholar 

  • Makris, A., Ryan, K.J., Yasymizu, T., Hill, C.L., and Zetter, B.R., 1984, The nonluteal porcine ovary as a source of angiogenic activity. Endocrinology 115:1672–1677.

    Article  PubMed  CAS  Google Scholar 

  • Markee, J.E., 1932, An analysis of the rhythmic vascular changes in the uterus of the rabbit. Am. J. Physiol. 100:374–383.

    Google Scholar 

  • Markee, J.E., 1940, Menstruation in intraocular endometrial transplants in the rhesus monkey. Contrib. Embryol. 28:221–308.

    Google Scholar 

  • Meegdes, H.L.M., Ingenhoes, R., Peeters, L.L.H., and Exalto, N., 1988, Early pregnancy wastage: relationship between chorionic vascularization and embryonic development. Fertil. Steril. 49:216–220.

    PubMed  CAS  Google Scholar 

  • Meschia, G., 1983, Circulation to female reproductive organs. In: Handbook of physiology, edited by Shepherd, J.T., Abboud, F.M., Sec 2, Vol. m, Part 1, pp 241–269. Amer. Physiol. Soc., Bethesda.

    Google Scholar 

  • Millaway, D.S., Redmer, D.A., Kirsch, J.D., Anthony, R.V., and Reynolds, L.P., 1989, Angiogenic activity of maternal and fetal placental tissues of ewes throughout gestation, J. Reprod. Fertil. 86: 689–696.

    Article  PubMed  CAS  Google Scholar 

  • Moor, R.M., and Seamark, R.F., 1986, Cell signaling, permeability, and microvasculatory changes during antral follicle development in mammals. J. Dairy Sci. 69:927–943.

    Article  PubMed  CAS  Google Scholar 

  • Moscatelli, D., Joseph-Silverstein, J., Presta, M., and Rifkin, D.B., 1988, Multiple forms of an angiogenesis factor: Basic fibroblast growth factor. Biochimie 70:83–87.

    Article  PubMed  CAS  Google Scholar 

  • Nephew, K.P., K.E. McClure, and W.F. Pope., 1989, Embryonic migration relative to maternal recognition of pregnancy in sheep. J. Anim. Sci. 67:999–1005.

    PubMed  CAS  Google Scholar 

  • Neufeld, G., Ferrara, N., Schweigerer, L., Mitchell, R., and Gospodarowicz, D., 1987, Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology 121:597–603.

    Article  PubMed  CAS  Google Scholar 

  • Nicosia, S.V., Diaz, J., Nicosia, R.F., Saunders, B.O., and Muro-Cacho, C, 1995, Cell proliferation and apoptosis during development and aging of the rabbit corpus luteum, Ann. Clin. Lab. Sci. 25: 143–157.

    PubMed  CAS  Google Scholar 

  • Niswender, G.D., and Nett, T.M., 1988, The corpus luteum and its control. In: The physiology of reproduction, edited by Knobil, E., Neill, J., et al., pp 489–525. Raven Press, New York.

    Google Scholar 

  • Niswender, G.D., Schwall, R.H., Fitz, T. A., Farin, CE., and Sawyer, H.R., 1985, Regulation of luteal function in domestic ruminants: New concepts. Rec. Prog. Horm. Res. 41:101–151.

    PubMed  CAS  Google Scholar 

  • Phillips, H.S., Hains, J., Leung, D.W., and Ferrara, N, 1990, Vascular endothelial growth factor is expresses in rat corpus luteum, Endocrinology 127:965–967.

    Article  PubMed  CAS  Google Scholar 

  • Presta, M., 1988, Sex hormones modulate the synthesis of basic fibroblast growth factor in human endometrial adenocarcinoma cells: implications for the neovascularization of normal and neoplastic endometrium. J. Cell. Physiol. 137:593–597.

    Article  PubMed  CAS  Google Scholar 

  • Ramsey, E.M., 1982, The placenta, human and animal. Praeger, New York.

    Google Scholar 

  • Ramsey, E.M., 1989, Vascular anatomy. In: Biology of the uterus, edited by Wynn, R.M., Jollie, W.P., pp 57–68. Plenum, New York.

    Google Scholar 

  • Redmer, D.A., Rone, J.D., and Goodman, A.L., 1985a, Detection of angiotropic activity from primate dominant follicles. 67th Annu. Meeting Endocr. Soc, p 151, abstr 604.

    Google Scholar 

  • Redmer, D.A., Rone, J.D., and Goodman, A.L., 1985b, Evidence for a non-steroidal angiotropic factor from the primate corpus luteum: Stimulation of endothelial cell migration in vitro. Proc. Soc. Exp. Biol. Med. 179:136–140.

    PubMed  CAS  Google Scholar 

  • Redmer, D.A., Kirsch, J.D., and Grazul, AT., 1987, In vitro production of angiotropic factor by bovine corpus luteum: partial characterization of activities that are chemotactic and mitogenic for endometrial cells. In: Regulation of ovarian and testicular function, edited by Dhindsa, D., Anderson, E., Kalra, S., pp 683–688. Plenum Press, New York.

    Google Scholar 

  • Redmer, D.A., Grazul, A.T., Kirsch, J.D., and Reynolds, L.P., 1988a, Angiogenic activity of bovine corpora lutea at several stages of luteal development. J. Reprod. Fert. 82:627–634.

    Article  CAS  Google Scholar 

  • Redmer, D. A., Grazul, A.T., and Reynolds, L.P., 1988b, Secretion of angiogenic activity by ovine and bovine corpora lutea throughout pregnancy. J. Reprod. Fert. Abst. Ser. 1:57.

    Google Scholar 

  • Redmer, D.A., Kirsch, J.D., and Reynolds, L.P., 1991, Production of mitogenic factors by cell types of bovine large estrogen-active and estrogen-inactive follicles. J. Anim. Sci. 69:237–245.

    PubMed  CAS  Google Scholar 

  • Reynolds, L.P., 1986, Utero-ovarian interactions during early pregnancy: role of conceptus-induced vasodilation. J. Anim. Sci. 62(Suppl. 2,:47–61.

    PubMed  Google Scholar 

  • Reynolds, L.P., and Redmer, D.A., 1988a, Secretion of angiogenic activity by placental tissues of cows at several stages of gestation. J. Reprod. Fert. 83:497–502.

    Article  CAS  Google Scholar 

  • Reynolds, L.P., and Redmer, D.A., 1988b, Secretion of angiogenic activity by endometrial tissues of cyclic and ovariectomized, steroid-treated ewes. J. Reprod. Fert. Abstr. Ser. 1:43.

    Google Scholar 

  • Reynolds, L.P., and Redmer, D.A., 1992, Growth and microvascular development of the uterus during early pregnancy in ewes. Biol. Reprod. 47:(In press,.

    Google Scholar 

  • Reynolds, L.P. and D.A. Redmer. 1995. Utero-placental vascular development and placental function. Review Article. J. Anim. Sci. 73:1839–1851.

    PubMed  CAS  Google Scholar 

  • Reynolds, L.P., Magness, R.R., and Ford, S.P., 1984, Uterine blood flow during early pregnancy in ewes: interaction between the conceptus and the ovary bearing the corpus luteum. J. Anim. Sci. 58:423–429.

    PubMed  CAS  Google Scholar 

  • Reynolds, L.P., Ferrell, C.L., Robertson, D.A., and Ford, S.P., 1986, Metabolism of the gravid uterus, foetus and uteroplacenta at several stages of gestation in cows. J. Agric. Sci., Cambridge 106:437–444.

    Article  CAS  Google Scholar 

  • Reynolds, L.P., Millaway, D.S., Kirsch, J.D., Infeld, J.E., and Redmer, D.A., 1987, Angiogenic activity of placental tissues of cows. J. Reprod. Fert. 81:233–240.

    Article  CAS  Google Scholar 

  • Reynolds, L.P., Millaway, D.S., Kirsch, J.D., Infeld, J.E., and Redmer, D.A., 1990, Growth and in vitro metabolism of placental tissues of cows from day 100 to day 250 of gestation. J. Reprod. Fert. 89:213–222.

    Article  CAS  Google Scholar 

  • Reynolds, L.P., Killilea, S.D., and Redmer, D.A., 1992, Angiogenesis in the female reproductive system. FASEB J. 6:886–892

    PubMed  CAS  Google Scholar 

  • Reynolds, L.P., A.T. Grazul-Bilska, S.D. Killilea and D.A. Redmer, 1993a, Angiogenesis in the female reproductive system: Patterns and mediators. In: Local Systems in Reproduction, R.R. Magness and F. Naftolin, eds.,, Serono Symp. Publ. Vol. 96. Raven Press, NY, pp 189–211.

    Google Scholar 

  • Reynolds, L.P., Killilea, S.D., and Redmer, D.A., 1993b, Endometrial growth and vascular development: Patterns and mediators. In: Exogenous hormones and dysfunctional uterine bleeding, edited by Alexander, N.J., D’Arcangues, C., AAAS Press, New York, NY, pp 35–48..

    Google Scholar 

  • Reynolds, L.P., S.D. Killilea, A.T. Grazul-Bilska and D.A. Redmer. 1994. Mitogenic factors of corpora lutea. Review Article. Progr. Growth Factor Res. 5:159–175.

    Article  CAS  Google Scholar 

  • Reynolds, L.P., J.D. Kirsch, K.C. Kraft and D.A. Redmer. 1995. Time-course of the uterine response to estradiol-17β, E2, in ovariectomized, OVX, ewes: Uterine growth and cell proliferation. Biol. Reprod. 52(Suppl.)::119.

    Google Scholar 

  • Ricke, W.A., D.A. Redmer and L.P. Reynolds. 1995a. Cellular growth of porcine corpora lutea throughout the estrous cycle. J. Anim. Sci. 73, Suppl. 1,:(In press,.

    Google Scholar 

  • Ricke, W.A., D.A. Redmer and L.P. Reynolds. 1995b. Initial characterization of mitogenic factors produced by porcine corpora lutea throughout the estrous cycle. Biol. Reprod. 52(Suppl. 1,:(Accepted).

    Google Scholar 

  • Shepro, D., and D’Amore, P.A., 1984, Physiology and biochemistry of the vascular wall endothelium. In: Handbook of physiology, edited by Renkin, E.M., Michel, C.C., Vol. IV, pp 103–164. Waverly Press, Baltimore.

    Google Scholar 

  • Stirling, D., Magness, R.R., Stone, R., Waterman, M.R., and Simpson, E.R., 1990, Angiotensin II inhibits luteinizing hormone-stimulated cholesterol side chain cleavage expression and stimulates basic fibroblast growth factor expression in bovine luteal cells in primary culture. J. Biol. Chem. 265:5–8.

    PubMed  CAS  Google Scholar 

  • Stirling, D., Waterman, MR., and Simpson, E.R., 1991, Expression of mRNA encoding basic fibroblast growth factor, bFGF, in bovine corpora lutea and cultured luteal cells. J. Reprod. Fert. 91:1–8.

    Article  CAS  Google Scholar 

  • Taraska, T., Reynolds, L.P., and Redmer, D.A., 1989, In vitro secretion of angiogenic activity by ovine follicles. In: Growth factors and the ovary, edited by Hirshfield, A., pp 267–272. Plenum, New York.

    Google Scholar 

  • Teasdale, F., 1976, Numerical density of nuclei in the sheep placenta. Anat. Rec. 185:187–196.

    Article  Google Scholar 

  • Tiollier, J., Uhlrich, S., Chirouze, V., Tardy, M., and Tayot, J.-L., 1990, Biochemical and biological characterization of a crude growth factor extract, EAP, from placental tissue. In: Placental Communications: Biochemical, Morphological and Cellular Aspects. INSERM, Natl. Inst, of Health and Med. Res., France, Colloquium, 199:98–100, John Libbey Eurotext, London.

    Google Scholar 

  • Vlodavsky, I., G. Korner, and R. Ishaimichaeli, et al., 1990, Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. Cancer Metastasis Rev 9:203–26.

    Article  PubMed  CAS  Google Scholar 

  • Weidner, N., Semple, J.P., Welch, W.R., and Folkman, J., 1991, Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. New England J. Med. 324:1–8.

    Article  CAS  Google Scholar 

  • Wimsatt, W.A., 1950, New histological observations on the placenta of the sheep. Am J Anat 87:391–457. Yan, Z.,

    Article  PubMed  CAS  Google Scholar 

  • Weich, H.A., Bernart, W., Breckwoldt, M., and Neulen, J., 1993, Vascular endothelial growth factor (VEGF) messenger ribonucleic acid, mRNA, expression in luteinized human granulosa cells in vitro, J. Clin. Endocrinol. Metab. 77: 1723–1725.

    Article  PubMed  Google Scholar 

  • Yasuda, T., Grinspan, J., Stern, J., Franceschini, B., Bannerman, P., and Pleasure, D., 1995, Apoptosis occurs in the oligodendroglial lineage, and is prevented by basic fibroblast growth factor, J. Neurosci. Res. 40: 306–317.

    Article  PubMed  CAS  Google Scholar 

  • Zeleznik, A.J., Schiler, H.M., and Reichert, L.E., 1981, Gonadotropin-binding sites in the Rhesus monkey ovary: Role of the vasculature in the selective distribution of human chorionic gonadotropin to the preovulatory follicle. Endocrinology 109:356–361.

    Article  PubMed  CAS  Google Scholar 

  • Zheng, J., 1995, Studies of uterine growth during early pregnancy in ewes, Ph.D. Dissertion, North Dakota State University, Fargo, ND, USA.

    Google Scholar 

  • Zheng, J., D.A. Redmer and L.P. Reynolds. 1993. Vascular development and heparin-binding growth factors in the bovine corpus luteum at several stages of the estrous cycle. Biol. Reprod. 49:1177–1189.

    Article  CAS  Google Scholar 

  • Zheng, J., P.M. Fricke, L.P. Reynolds and D.A. Redmer. 1994. Evaluation of growth, cell proliferation, and cell death in bovine corpora lutea throughout the estrous cycle. Biol. Reprod. 51.623–632.

    Article  CAS  Google Scholar 

  • Zheng, J., A.T. Grazul-Bilska, V. Doraiswamy, D.A. Redmer and L.P. Reynolds. 1995a. Ovine endometrium of early pregnancy secretes an angiogenic factor that stimulates endothelial cell migration. Biol. Reprod. 52(Suppl. 1):190.

    Google Scholar 

  • Zheng, J., R.R. Magness, D.A. Redmer and L.P. Reynolds. 1995b. Angiogenic activity of ovine placental tissues: Immunoneutralization with FGF-2 and VEGF antisera. J. Soc. Gynecol. Invest. 2(2):289 (Abstr. P146).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Animal & Range Sciences, USA

    Lawrence P. Reynolds & Dale A. Redmer

  2. Cell Biology Center, USA

    Anna T. Grazul-Bilska

  3. Department of Biochemistry, North Dakota State University, Fargo, ND, 58105, USA

    S. Derek Killilea

  4. Department of Development and Signalling, Babraham Institute, Babraham, Cambridge, CB2 AT, UK

    R. M. Moor

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  1. Lawrence P. Reynolds
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  2. Dale A. Redmer
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  3. Anna T. Grazul-Bilska
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  4. S. Derek Killilea
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  5. R. M. Moor
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  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

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© 1996 Plenum Press, New York

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Reynolds, L.P., Redmer, D.A., Grazul-Bilska, A.T., Killilea, S.D., Moor, R.M. (1996). Angiogenesis in the Female Reproductive Organs. In: Maragoudakis, M.E. (eds) Molecular, Cellular, and Clinical Aspects of Angiogenesis. NATO ASI Series, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0389-3_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0389-3_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8030-6

  • Online ISBN: 978-1-4613-0389-3

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