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Signal Transduction Pathways and the Regulation of Angiogenesis

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Book cover Molecular, Cellular, and Clinical Aspects of Angiogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 285))

Abstract

All through the 1970s the long search for an elusive angiogenic factor has caused skepticism for the concept proposed by Folkman (1972) that tumors secrete promoters of angiogenesis. In 1983 Folkman and his colleagues have succeeded in isolating a heparin binding factor and a year later Guilleman’s laboratory described the amino acid sequence of b-FGF (Folkman, 1985). Today we have numerous factors that have been reported to either promote or suppress angiogenesis. Many of them have been sequenced and their genes cloned. A partial list of angiogenic substances are shown in Table 1. The relative contribution of these factors in the control of physiological and pathological angiogenesis remains to be elucidated. All the angiogenic factors listed in Table 1 do not satisfy to the same extent the critiria for an in vivo angiogenic factor such as VEGF. For VEGF it has been shown that it specifically stimulates mitogenic activity and invasion into extracellular matrix and tube formation of endothelial cells only. In addition VEGF promotes angiogenesis in vivo and there is a temporal and spatial formation of VEGF in all types of angiogenesis (embryonic, ovulation and cancer). m-RNA for the receptor of VEGF and binding to the receptor during angiogenesis is demonstrated only in the proliferating endothelial cells. Furthemore, inhibition of the production of VEGF or the expression of the receptor leads to inhibition of angiogenesis and tumor growth.

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Authors and Affiliations

  1. Dept. of Pharmacology, University of Patras Medical School, 261 10, Patras, Greece

    Michael E. Maragoudakis

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  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

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© 1996 Plenum Press, New York

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Maragoudakis, M.E. (1996). Signal Transduction Pathways and the Regulation of Angiogenesis. In: Maragoudakis, M.E. (eds) Molecular, Cellular, and Clinical Aspects of Angiogenesis. NATO ASI Series, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0389-3_11

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  • DOI: https://doi.org/10.1007/978-1-4613-0389-3_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8030-6

  • Online ISBN: 978-1-4613-0389-3

  • eBook Packages: Springer Book Archive

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