Serotoninergic Block in the Ventromedial Nucleus of Hypothalamus Improves Food Intake in Anorectic Tumor Bearing Rats
In animal models, cancer associated anorexia has been extensively investigated. We recently showed that cancer anorexia is primarily a centrally mediated phenomenon, in which the ventromedial nucleus of hypothalamus (VMH) plays a significant role (Laviano et al., 1995). Under normal conditions, VMH is known to significantly participates in mediating satiety, primarily via the neurotransmitter serotonin (Leibowitz, 1990). Serotonin has also been postulated to mediate cancer anorexia (Rossi Fanelli and Cangiano, 1991), and the previously reported involvement of VMH, a predominantly serotoninergic nucleus, in the development of reduced food intake during tumor growth is in agreement with this supposition (Laviano et al., 1995).
KeywordsCage Serotonin Sarcoma Tryptophan Catecholamine
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