Effect of Valine on 5-HT Neurotransmission and Mood

  • P. J. Cowen
  • D. J. Williamson
  • S. F. B. McTavish
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 398)

Abstract

Changes in brain serotonin (5-HT) function have been implicated in both the aetiology of mood disorders and the actions of antidepressant drugs (for reviews see Delgado et al, 1992; Cowen, 1993). Recently, Delgado et al (1990) have reported that a 100g amino acid mixture, free of the 5-HT precursor, L-tryptophan (TRP), causes an acute symptomatic relapse in remitted depressed patients maintained on antidepressant drugs. This relapse has been attributed to an abrupt decline in the availability of TRP for brain 5-HT synthesis which temporarily reverses the effects of the antidepressant drug treatment.

Keywords

Placebo Depression Lithium Attenuation Tyrosine 

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References

  1. Cowen, P.J., 1993, Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation, Clin Neuropharmacol. 16 (Suppl 3), S6 - S18.Google Scholar
  2. Delgado, P.L., Charney, D.S., Price, L.H., et al, 1990, Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan, Arch Gen Psychiat, 47, 411.Google Scholar
  3. Delgado, P.L., Price, L.H., Heninger, G.R., et al, 1992, Neurochemistry, in “Handbook of Affective Disorders,” E.S. Paykel, Churchill Livingstone, Edinburgh.Google Scholar
  4. Gartside, S.E., Cowen, P.J. & Sharp, T., 1992a, Evidence that the large neutral amino acid L-valine decreases electrically-evoked release of 5-HT in rat hippocampus in vivo. Psychopharmacol, 109, 251.CrossRefGoogle Scholar
  5. Gartside, S.E., Cowen, P.J. & Sharp, T., 1992b, Effect of amino acid loads on hippocampal 5-HT release in vivoevoked by electrical stimulation of the dorsal raphe nucleus and d-fenfluramine administration, Brit J Pharmacol107, 448 P.Google Scholar
  6. Joseph, G.A. and Kennett, G.A., 1983, Corticosteroid response to stress depends upon increased tryptophan availability, Psychopharmacol, 79, 79.CrossRefGoogle Scholar
  7. Lehnert, H. & Wurtman, R.J., 1993, Amino acid control of neurotransmitter synthesis and release: physiological and clinical implications, Psychotherapeut Psychosomat, 60, 18CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • P. J. Cowen
    • 1
  • D. J. Williamson
    • 1
  • S. F. B. McTavish
    • 1
  1. 1.Department of PsychiatryLittlemore HospitalOxfordUK

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