Nicotinamide Methyltransferase Activity and Cell-Death in the Liver of the Mouse Bearing Ehrlich Ascites Tumor
In order to develop new ways of tumor diagnosis and therapy, it is important to know the metabolic changes occurring while bearing the tumor, since these ways should be applied to the cancer patient, who is, after all, a tumor bearer. Various metabolic changes in the tumor host tissues, especially in the liver, have been observed to take place together with tumor-growth (Fujimura and Shimizu, 1977; Shimizu and Fujimura, 1978; 1984; Asanagi et al., 1988; Tanaka et al., 1991; Nakagawa et al., 1991; Fujimura et al., 1992a; 1992b; Hanazawa et al., 1994; Fujimura et al., 1995).
KeywordsAscitic Fluid Aldehyde Oxidase Endometrial Cancer Patient Ehrlich Ascites Tumor Tumor Host
Unable to display preview. Download preview PDF.
- Clark B.R., Murai J.T., Pomeranz A., Mills P.A., and Smith R.A., 1975, Altered distribution and excretion of N1 -methylnicotinamide in rats with Walker 256 carcinosarcoma, Cancer Res. 35: 1727Google Scholar
- Fujimura S., Kato N., Han J.-Y., Hanazawa Y., and Nakagawa K., 1992a, Preferential increase of nicotinamide methyltransferase activity in the liver of the tumor host, in: “Frontiers and new horizons in amino acid research,” K. Takai, ed., Elsevier Science Publishers B.V., AmsterdamGoogle Scholar
- Fujimura S., Kato N., Han J.-Y., Hanazawa Y., Nakagawa K., and Horitsu K., 1992b, Increase of nicotinamide methyltransferase activity in the liver of the mouse after transplantation of Ehrlich ascites tumor, in: “Advances in Tryptophan Research,” I. Ishiguro et al. eds., Fujita Health Univ. Press, ToyoakeGoogle Scholar
- Fujimura S., Kato N., Tanaka N., and Moriyama Y., 1995, Acidic a1-proteinase inhibitor species in the ascitic fluid of the mouse bearing Ehrlich ascites tumor and the endometrial cancer patient, in: “Proteases involved in cancer,” M. Suzuki and T. Hiwasa, eds., Monduzzi Editore, BolognaGoogle Scholar
- Fukuda K., Kojima M., and Chiu J.-F., 1993, Demonstration of extensive chromatin cleavage in transplanted Morris Hepatoma 111 tissue: apoptosis or not? Am J Pathol142: 935Google Scholar
- Hanazawa Y., Sato K., Kuroiwa N., Ogawa M., Kuriyama A., Asanagi M., Kato N., Moriyama Y., Horitsu K., and Fujimura S., 1994, Characterization of nicotinamide methyltransferase in livers of mice bearing Ehrlich ascites tumors; Preferential increase of activity, Tumor Biol. 15: 7CrossRefGoogle Scholar
- Nakagawa K., Miyazaki M., Okui K., Kato N., Moriyama Y., and Fujimura S., 1991, N1-Methylnicotinamide level in the blood after nicotinamide loading as further evidence for malignant tumor burden, Jpn J Cancer Res82: 1277Google Scholar
- Shimizu M., and Fujimura S., 1978, Studies on the abnormal excretion of pyrimidine nucleosides in the urine of Yoshida ascites sarcoma-bearing rats, Biochim Biophys Acta517: 277Google Scholar
- Shimizu M., and Fujimura S., 1984, Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma, Cancer Res. 44: 2387Google Scholar
- Tanaka N., Sekiya S., Takamizawa H., Kato N., Moriyama Y., and Fujimura S., 1991, Characterization of a 54kDa, a1-antitrypsin- like protein isolated from ascitic fluid of an endometrial cancer patient, Jpn J Cancer Res82: 693Google Scholar