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Nicotinamide Methyltransferase Activity and Cell-Death in the Liver of the Mouse Bearing Ehrlich Ascites Tumor

  • S. Fujimura
  • A. Okamura
  • Y. Ohmura
  • Y. Moriyama
  • H. Ohwada
  • K. Horitsu
  • M. Ohkubo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 398)

Abstract

In order to develop new ways of tumor diagnosis and therapy, it is important to know the metabolic changes occurring while bearing the tumor, since these ways should be applied to the cancer patient, who is, after all, a tumor bearer. Various metabolic changes in the tumor host tissues, especially in the liver, have been observed to take place together with tumor-growth (Fujimura and Shimizu, 1977; Shimizu and Fujimura, 1978; 1984; Asanagi et al., 1988; Tanaka et al., 1991; Nakagawa et al., 1991; Fujimura et al., 1992a; 1992b; Hanazawa et al., 1994; Fujimura et al., 1995).

Keywords

Ascitic Fluid Aldehyde Oxidase Endometrial Cancer Patient Ehrlich Ascites Tumor Tumor Host 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Asanagi M., Moriyama Y., and Fujimura S., 1988, Purification and characterization of thymidylate synthetase in the liver of the mouse bearing Ehrlich ascites tumor, Arch Biochem Biophys267: 749CrossRefGoogle Scholar
  2. Benedetti A., Jezequel A.M., and Orlandi F., 1988, Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver, J Hepatol7: 319CrossRefGoogle Scholar
  3. Clark B.R., Murai J.T., Pomeranz A., Mills P.A., and Smith R.A., 1975, Altered distribution and excretion of N1 -methylnicotinamide in rats with Walker 256 carcinosarcoma, Cancer Res. 35: 1727Google Scholar
  4. Fujimura S., and Shimizu M., 1977, Enhanced activity of tRNA-pseudouridine synthetase in Yoshida sarcoma, Biochem Biophys Res Commun79: 763CrossRefGoogle Scholar
  5. Fujimura S., Kato N., Han J.-Y., Hanazawa Y., and Nakagawa K., 1992a, Preferential increase of nicotinamide methyltransferase activity in the liver of the tumor host, in: “Frontiers and new horizons in amino acid research,” K. Takai, ed., Elsevier Science Publishers B.V., AmsterdamGoogle Scholar
  6. Fujimura S., Kato N., Han J.-Y., Hanazawa Y., Nakagawa K., and Horitsu K., 1992b, Increase of nicotinamide methyltransferase activity in the liver of the mouse after transplantation of Ehrlich ascites tumor, in: “Advances in Tryptophan Research,” I. Ishiguro et al. eds., Fujita Health Univ. Press, ToyoakeGoogle Scholar
  7. Fujimura S., Kato N., Tanaka N., and Moriyama Y., 1995, Acidic a1-proteinase inhibitor species in the ascitic fluid of the mouse bearing Ehrlich ascites tumor and the endometrial cancer patient, in: “Proteases involved in cancer,” M. Suzuki and T. Hiwasa, eds., Monduzzi Editore, BolognaGoogle Scholar
  8. Fukuda K., Kojima M., and Chiu J.-F., 1993, Demonstration of extensive chromatin cleavage in transplanted Morris Hepatoma 111 tissue: apoptosis or not? Am J Pathol142: 935Google Scholar
  9. Hanazawa Y., Sato K., Kuroiwa N., Ogawa M., Kuriyama A., Asanagi M., Kato N., Moriyama Y., Horitsu K., and Fujimura S., 1994, Characterization of nicotinamide methyltransferase in livers of mice bearing Ehrlich ascites tumors; Preferential increase of activity, Tumor Biol. 15: 7CrossRefGoogle Scholar
  10. Maria L., Maria L., Barreira L., and Manso C.F., 1995, Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism, Arch Biochem Biophys318: 53CrossRefGoogle Scholar
  11. Nakagawa K., Miyazaki M., Okui K., Kato N., Moriyama Y., and Fujimura S., 1991, N1-Methylnicotinamide level in the blood after nicotinamide loading as further evidence for malignant tumor burden, Jpn J Cancer Res82: 1277Google Scholar
  12. Ogasawara J., Watanabe-Fukunaga R., Adachi M., Matsuzawa A., Kasugai T., Kitamura Y., Ito N., Suda T. and Nagata S., 1993, Lethal effect of the anti-Fas antibody in mice, Nature364: 808CrossRefGoogle Scholar
  13. Shimizu M., and Fujimura S., 1978, Studies on the abnormal excretion of pyrimidine nucleosides in the urine of Yoshida ascites sarcoma-bearing rats, Biochim Biophys Acta517: 277Google Scholar
  14. Shimizu M., and Fujimura S., 1984, Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma, Cancer Res. 44: 2387Google Scholar
  15. Tanaka N., Sekiya S., Takamizawa H., Kato N., Moriyama Y., and Fujimura S., 1991, Characterization of a 54kDa, a1-antitrypsin- like protein isolated from ascitic fluid of an endometrial cancer patient, Jpn J Cancer Res82: 693Google Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • S. Fujimura
    • 1
  • A. Okamura
    • 1
  • Y. Ohmura
    • 1
  • Y. Moriyama
    • 1
  • H. Ohwada
    • 2
  • K. Horitsu
    • 3
  • M. Ohkubo
    • 4
  1. 1.Department of BiochemistryChiba University School of MedicineJapan
  2. 2.Department of Pathology, Institute for Lung Cancer ResearchChiba University School of MedicineChuo-ku, ChibaJapan
  3. 3.Faculty of Home EconomicsTokyo Kasei UniversityItabashi-ku, TokyoJapan
  4. 4.Kagoshima Immaculate Heart CollegeKagoshimaJapan

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