Abstract
The association between hypercholesterolemia and atherosclerosis in humans is widely accepted (Goldstein and Brown, 1977; Steinberg, 1983; Nordoy and Goodnight, 1990). Some studies (Muldoon et al., 1990) have shown that a decrease in serum cholesterol in middle-aged subjects by diet, drugs or both, leads to a significant reduction of the incidence of coronary heart disease, although total mortality is not affected by treatment, while higher mortality due to suicide or violence is observed among people undergoing treatment to lower serum cholesterol concentrations. Therefore, Engelberg (1992) suggested association between serum cholesterol levels, neuronal function and behavioural predisposition. The same author found that anomalies in brain serotonin were associated to reduced control of instinctive impulses.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Allain C.C., Poom L.S., Chan C.S., 1974, Enzymatic determination of total serum cholesterol, Clin.Chem., 20:470.
Burstein M., Scholnick H.R., Morgin R., 1970, Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions, J.Lipid Res., 11:583.
Costa C., Bettero A., Allegri G., 1987, Rapid measurements of tryptophan, 5-hydroxy trytophan, serotonin and 5-hydroxyindoleacetic acid in human CSF by selective fluorescence and HPLC, Giorn. It. Chim.Clin., 12:307.
Engelberg H., 1992, Low serum cholesterol and suicide, Lancet, 339:727.
Friedewald W.T., Levy R.I., Fredrickson D.S., 1972, Estimation of plasma low density lipoproteins cholesterol concentration without use of the preparative ultracentrifuge, Clin.Chem. 18:499.
Goldstein J.L., Brown M.S., 1977, Low density lipoprotein pathway and its relations to atherosclerosis, Annu. Rev. Biochem., 46:897.
Heron D.S., Shinitzky M., Herrshkowitz M., and Samuel D., 1980, Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes, Proc.Natl.Acad.Sci. USA, 77:7463.
McMenamy R.H., Oncley J.L., 1958, The specific binding of tryptophan to serum albumin, J.Biol.Chem233:1436.
Muldoon M.F., Manuck. S.B, Mathews K.M., 1990, Lowering cholesterol concentrations and mortality:a quantitative review of primary prevention trial, Br. Med. J., 301:309.
Nordoy A, Goodnight S.H., 1990, Dietary lipids and thrombosis, Relationship to atherosclerosis, Arteriosclerosis, 10:149.
Steinberg D., 1983, Lipoproteins and atherosclerosis. A look back and a look ahead, Arteriosclerosis, 3:283.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Plenum Press, New York
About this chapter
Cite this chapter
Baldo-Enzi, G., Baiocchi, M.R., Bertazzo, A., Costa, C.V.L., Allegri, G. (1996). Tryptophan and Atherosclerosis. In: Filippini, G.A., Costa, C.V.L., Bertazzo, A. (eds) Recent Advances in Tryptophan Research. Advances in Experimental Medicine and Biology, vol 398. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0381-7_67
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0381-7_67
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-8026-9
Online ISBN: 978-1-4613-0381-7
eBook Packages: Springer Book Archive