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Quinolinic Acid and Active Oxygens

Possible Contribution of Active Oxygens during Cell Death in the Brain
  • K. Goda
  • R. Kishimoto
  • S. Shimizu
  • Y. Hamane
  • M. Ueda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 398)

Abstract

Quinolinic acid (QA, pyridine-2,3-dicarboxylic acid) is an intermediate of the kynurenine pathway in the tryptophan metabolism, which has been detected in the central nervous system (Gal and Sherman, 1978; Speciale and Schwarcz, 1993), and behaves as an excitotoxin (Lapin, 1978; Schwarcz et al., 1983). Recently, it has been proposed that QA and other metabolites of tryptophan may be involved in the brain pathology accompanying neuroinflammatory conditions, and also implicated in the pathophysiology of brain ischemia (Jhamandas and Boegman, 1994). The neuroexcitatory and neurotoxic actions have been suggested to be mediated by NMDA receptor (recently, its subtypes) (Schwarcz et al., 1984; Nakanishi, 1992),. However, the proximate cause of cell death at metabolic level has remained elusive. In the brain, there are numerous sources of oxygen-derived free radicals and they may exert a large variety of effects upon importnat central nervous system functions. Several studies have pointed to the role of metal ions, especially iron, in forming oxygen-derived free radicals (Barber, 1966; Vladimirov et al., 1980), which introduce several reactions such as lipid peroxidation, DNA chain breakage and others in the brain. The purpose of this experiment was to see the interaction of QA with iron ion (complex formation), the electron transfer to oxygen molecules from the complex (superoxide formation) and superoxide-mediated reactions such as lipid peroxidation and DNA chain breakage in vitro. Also, tryptophan metabolites which are known to be antagonist for QA were examined in the QA-iron system.

Keywords

Lipid Peroxidation Active Oxygen Quinolinic Acid Kynurenic Acid Kynurenine Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • K. Goda
    • 1
  • R. Kishimoto
    • 1
  • S. Shimizu
    • 1
  • Y. Hamane
    • 1
  • M. Ueda
    • 1
  1. 1.Department of NutritionKobe Gakuin UniversityKobeJapan

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