Marine Natural Products
The difference between a harmful toxin and a beneficial drug is largely a matter of dose. Historically, toxins provided important leads towards drug discovery, as their purification could be followed by a readily available and unambiguous bioassay — death of a small rodent. Modern sensitive enzyme-based assays have made all natural products — organic compounds isolated from living organisms — a potential source for drug discovery. The oceans of the earth which cover 70% of its surface and are the habitat of a rich and diverse fauna and flora, much of it still to be discovered and described, offer a prime resource for new molecular structures with a broad spectrum of bioactivities.
KeywordsMorphine Pseudomonas Alkaloid Cane Indole
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