How is the Dioxygen-Iron Bond Manipulated by Transport and Catalytic Haem Proteins?
The Chemistry which underpins corrosion has been borrowed by evolutionary biology and used to perform a myriad of cunning feats. The lecture will exemplify this by showing that the first stage of the reaction involving corrosion forms the basis of the mechanism of transport of oxygen by haemoglobin. In turn, the chemistry underpinning the latter process represents a fundamental reaction from which more complex biological oxidative reactions have evolved. These reactions are catalysed by drug-metabolising hydroxylases of the cytochrome P-450 family but more importantly, from the viewpoint of the lecture, by multifunctional cytochrome P-450s involved in the biosynthesis of sex hormones.
KeywordsHaem Iron Hydroxylation Reaction Androgen Biosynthesis High Spin Iron Negative Gibbs Free Energy
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