Vaccines pp 147-160 | Cite as

DNA-Based Immunization: Prospects For a Hepatitis B Vaccine

  • Heather L. Davis
  • Robert G. Whalen
Part of the Nato Science Series book series (NSSA, volume 282)


Nucleic acid-based immunization refers to the induction of an immune response to an antigen expressedin vivo subsequent to the introduction of coding sequences in the form of either DNA or RNA. To date, most examples of nucleic acid-based immunization have used DNA encoding a polypeptide sequence, thus the subsequent discussion will be restricted to DNA-based immunization (for an example of an RNA-based vaccine, see Martinon et al., 1993). Administration of DNA encoding an antigen as a vaccine potentially offers several advantages over administration of the antigen itself, as is the case with many classical vaccines used currently in humans. These advantages and their significance are discussed in the next part (Section II).


Tibialis Anterior Subunit Vaccine Direct Gene Transfer Rabies Virus Glycoprotein 
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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • Heather L. Davis
    • 1
    • 2
  • Robert G. Whalen
    • 2
  1. 1.Loeb Medical Research Institute, Ottawa Civic HospitalFaculties of Health Sciences and Medicine, University of OttawaOttawaCanada
  2. 2.Département de Biologie MoléculaireInst PasteurParis cedexFrance

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