Abstract
Genetic engineering offers a variety of approaches of viral vaccines. An exciting advance in this field is the ability to construct virus-like particles that resemble their natural counterparts, but which lack genetic information (i.e., they are unable to replicate per se). We have developed two such structures (based on bluetongue virus particles), that have the additional important characteristic of incorporating many different epitopes into the same particle through the use of novel baculovirus multigene expression vectors. Bluetongue is an arthropod-borne disease of certain domestic animals (sheep, goats, cattle) and wild ruminants. The etiological agent is an orbivirus, BTV, belonging to the Reoviridae family. To date, some 24 different BTV serotypes have been identified (BTV-1, BTV-2, etc) from different parts of the world (Erasmus, 1990). Orbiviruses involve intermediate hosts as vectors in order to pass from animal to animal. Some of these viruses, e.g. BTV, AHSV and EHDV etc., utilise particular types of insects (gnats) as intermediates in their transmission from vertebrate to vertebrate.
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References
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© 1995 Plenum Press, New York
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Roy, P. (1995). Multicomponent Viral Vaccines and Their Use as Immunogen Delivery Systems. In: Gregoriadis, G., McCormack, B., Allison, A.C. (eds) Vaccines. Nato Science Series, vol 282. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0357-2_10
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DOI: https://doi.org/10.1007/978-1-4613-0357-2_10
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