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Vitamins C and E Alter the Response to Coronary Balloon Injury in the Pig

  • Gilberto L. Nunes
  • Spencer B. KingIII
  • Robert A. Redden
  • Steven R. Sigman
  • Bradford C. Berk
  • Demetrios S. Sgoutas
  • Michael B. Gravanis
Part of the NATO ASI Series book series (NSSA, volume 281)

Abstract

Restenosis after percutaneous transluminal coronary angioplasty is the major limitation of the long-term success of this procedure (Holmes et al., 1984). The process of restenosis involves repair of vascular injury and remodeling of vessel architecture (Kuntz and Baim, 1993). Therapeutic interventions that improve vascular function may therefore be beneficial in the treatment of restenosis (Kuntz et al.) Antioxidants such as probucol and vitamins C and E have proved effective in improving endothelial function in hypercholesterolemia, inhibiting lipid accumulation in animal models of atherosclerosis and decreasing cardiovascular mortality in humans (Halliwell, 1989).

Keywords

Vascular Remodel Vascular Response Balloon Injury Intimal Proliferation Domestic Swine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Halliwell, B., 1989, Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis. Br. J. Exp. Pathol. 70: 737–757PubMedGoogle Scholar
  2. Holmes, D.R., Vlietstra, R.E., Smith, H.C., Vetrovec, G.W., Kent, K.M., Cowley, M.J., Faxon, D.P., Gruentzig, A.R., Kelsey, S.F., Detre, K.M., Van Raden, M.J. and Mock, M.B., 1984, Restenosis after percutaneous transluminal coronary angioplasty (PTCA): A report from the PTCA registry of the National Heart, Lung and Blood Institute. Am. J. Cardiol. 53: 77C–81C.PubMedCrossRefGoogle Scholar
  3. Kuntz, R.E. and Baim, D.S., 1993, Defining coronary restenosis. Newer clinical and angiographic paradigms. Circulation 88: 1310–1323.PubMedGoogle Scholar
  4. Kuntz, R.E., Safian, R.D, Carrozza, J.P., Fishman, R.F., Mansour, M. and Baim, D.S., The importance of acute liminal diameter in determining restenosis after coronary atheroectomy or stenting.Google Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Gilberto L. Nunes
    • 1
    • 2
    • 3
  • Spencer B. KingIII
    • 1
    • 2
    • 3
  • Robert A. Redden
    • 1
    • 2
    • 3
  • Steven R. Sigman
    • 1
    • 2
    • 3
  • Bradford C. Berk
    • 1
    • 2
    • 3
  • Demetrios S. Sgoutas
    • 4
  • Michael B. Gravanis
    • 4
  1. 1.Department of MedicineUSA
  2. 2.Department of Cardiology DivisionUSA
  3. 3.Department of Andreas Gruentzig Cardiovascular CenterUSA
  4. 4.PathologyEmory University School of MedicineUSA

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