Vitamins C and E Alter the Response to Coronary Balloon Injury in the Pig
Restenosis after percutaneous transluminal coronary angioplasty is the major limitation of the long-term success of this procedure (Holmes et al., 1984). The process of restenosis involves repair of vascular injury and remodeling of vessel architecture (Kuntz and Baim, 1993). Therapeutic interventions that improve vascular function may therefore be beneficial in the treatment of restenosis (Kuntz et al.) Antioxidants such as probucol and vitamins C and E have proved effective in improving endothelial function in hypercholesterolemia, inhibiting lipid accumulation in animal models of atherosclerosis and decreasing cardiovascular mortality in humans (Halliwell, 1989).
KeywordsVascular Remodel Vascular Response Balloon Injury Intimal Proliferation Domestic Swine
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