Activation of Extrinsic Fibrinolysis During Cardiothoracic Operations with and without Cardiopulmonary Bypass (CPB)
Cardiac surgery using CPB is known to induce fibrinolytic activation. However the extent to which CPB itself induces these changes is not clear. The aim of this study was to assess activation of extrinsic fibrinolysis in cardiothoracic operations with and without CPB. Blood samples were collected from 8 patients receiving coronary artery bypass grafts using CPB, and 7 patients receiving thoracic operations without CPB (4 thoracotamies and 3 two-stage oesophagectomies). Sequential blood samples were taken from the CPB group at time points 1. pre-operatively, 2. pre-CPB, 3. 5 minutes after the start of CPB, 4. end of CPB, 5. 20 minutes post-operative, 6. 24 hours post-operative, 7. 48 hours post-operative. Samples from the thoracic group were taken at equivalent time intervals.
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