Role of Endothelium-Derived Platelet Activating Factor in Biological Responses to Thrombolytic Agents

  • E. Lupia
  • G. Montrucchio
  • G. Alloatti
  • S. Bergerone
  • F. Bussolino
  • F. Mariano
  • L. Silvetro
  • A. De Martino
  • G. Emanuelli
  • G. Camussi
Part of the NATO ASI Series book series (NSSA, volume 281)

Abstract

One limitation of administration of thrombolytic agents in patients with acute myocardial infarction (AMI) is that they can cause hypotension as well as alterations of platelet (PLT) functions (Ganz et al., 1984), which may limit the response to this therapy (Fitzgerald et al, 1988). The aim of the present study is to investigate whether platelet activating factor (PAF), an ether lipid mediator with multiple potent biological activities, including direct cardiovascular effects, is synthesized during the thrombolytic therapy. After streptokinase (SK) infusion (666 units/Kg/min for 60 minutes) in rabbits, we evaluated in vivo:
  • the generation of PAF in blood samples and cardiac and aortic perfusates;

  • the effect of two structurally unrelated PAF receptors antagonists, SDZ 63-675 and WEB 2170, on hypotension, thrombocytopenia and PLT hyperaggregability. In addition, we studied the intravascular release of PAF in patients with AMI treated or untreated with intravenous SK or plasmin.

Keywords

Thrombocytopenia Cardiol Fibrinogen Streptokinase Plasmin 

References

  1. Fitzgerald, D.J. et al., 1988, Circulation 77: 142–150.PubMedCrossRefGoogle Scholar
  2. Ganz, W. et al., 1984, Am. J. Cardiol. 53: 1209–1216.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • E. Lupia
    • 1
    • 2
  • G. Montrucchio
    • 1
    • 2
  • G. Alloatti
    • 1
    • 2
  • S. Bergerone
    • 1
    • 2
  • F. Bussolino
    • 1
    • 2
  • F. Mariano
    • 1
    • 2
  • L. Silvetro
    • 1
    • 2
  • A. De Martino
    • 1
    • 2
  • G. Emanuelli
    • 1
    • 2
  • G. Camussi
    • 1
    • 2
  1. 1.Department of Clinic Patho-PhysiologyUniversity of TurinNaplesItaly
  2. 2.Department of Clinic Patho-PhysiologyUniversity of NaplesNaplesItaly

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