Molecular Organization of Endothelial Cell to Cell Junctions
The endothelial monolayer forms the main barrier to macromolecular passage from blood to tissues and regulates the extravasation of circulating cells such as leukocytes. When endothelial permeability is altered such as in inflammatory conditions, edema takes place. Inflammatory edema is a significant component of many diseases e.g. adult respiratory syndrome, septicemia and hypoxia/reperfusion syndrome. This is frequently the result of both pressure-induced filtration of plasma proteins and changes in the permeability properties of the endothelial lining of the vascular wall (Majno et al., 1961).
KeywordsPermeability Migration Filtration Serotonin Histamine
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