Genetics of myo-Inositol Phosphate Synthesis and Accumulation

  • Victor Raboy
  • Paolo Gerbasi
Part of the Subcellular Biochemistry book series (SCBI, volume 26)


Two cellular functions for the myo-inositol (Ins) polyphosphate esters (Ins bis-, tris-, tetrakis-, pentakis-, and hexakisphosphate or phytic acid) are prominent in the literature. These are as metabolites in phosphate and mineral storage or regulation pathways and as metabolites in signal transduction pathways (see below). A third discrete function involves the modulation of hemoglobin oxygen affinity in the avian erythrocyte (Isaacks and Harkness, 1980). Recently Ins hexa-, hepta-, and octaphosphates containing one or two pyrophosphate moieties have been identified in a number of cell types (Mayr et al., 1992; Menniti et al., 1993). They are probably synthesized from Ins pentakis- and hexakisphosphate as part of a kinase-pyrophosphatase cycle. This cycle may represent an additional discrete role for Ins phosphate metabolism as a component of “high-energy” phosphate bond metabolism.


Phytic Acid Inositol Phosphate Retinal Degeneration Pleckstrin Homology Domain Inositol Polyphosphate 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Victor Raboy
    • 1
  • Paolo Gerbasi
    • 1
  1. 1.USDA-ARS Range Weeds and Cereals Research UnitMontana State UniversityBozemanUSA

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