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Control of the Ca2+ Release Induced by myo-Inositol Trisphosphate and the Implication in Signal Transduction

  • Chapter
myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction

Part of the book series: Subcellular Biochemistry ((SCBI,volume 26))

Abstract

Inositol-1,4,5-trisphosphate (InsP3) is a diffusible messenger formed within the cell in response to external stimuli. It mobilizes Ca2+ from those nonmitochondrial Ca2+ pools that express the InsP3 receptor (InsP3R), a specific Ca2+-release channel (Berridge and Irvine, 1989; Berridge, 1993). The nonmitochondrial pools were originally classified as InsP3-sensitive and InsP3insensitive. Recent evidence suggests that the InsP3-sensitive Ca2+ pool is much larger than hitherto expected (Bird et al., 1992) and that InsP3-insensitive Ca2+ pools can artifactually be formed during the permeabilization procedure (Hajnóczky et al., 1994). Under conditions of very mild permeabilization, 95% of the nonmitochondrial Ca2+ pools can be InsP3-sensitive, e.g., in A7r5 smooth muscle cells (Missiaen et al., 1992b).

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Abbreviations

InsP3 :

inositol-1,4,5-trisphosphate

InsP3R:

InsP3 receptor

PK A:

cyclic- AMP-dependent protein kinase

PKG:

cyclic-GMP-dependent protein kinase

[Ca2+]:

Ca2+ concentration

[Ca2+]i :

cytosolic Ca2+ concentration

PCR:

polymerase chain reaction

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Authors and Affiliations

  1. Laboratory for Physiology, Catholic University of Leuven, Campus Gasthuisberg, B-3000, Leuven, Belgium

    Ludwig Missiaen, Jan B. Parys, Humbert De Smedt, Ilse Sienaert & Rik Casteels

  2. The Babraham Institute Laboratory of Molecular Signaling, Department of Zoology, Cambridge University, Cambridge, CB2 3EJ, UK

    Martin D. Bootman

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  1. Ludwig Missiaen
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  2. Jan B. Parys
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  3. Humbert De Smedt
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  4. Ilse Sienaert
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  5. Martin D. Bootman
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  6. Rik Casteels
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Editors and Affiliations

  1. University of Calcutta, Calcutta, India

    B. B. Biswas

  2. Bose Institute, Calcutta, India

    Susweta Biswas

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© 1996 Plenum Press, New York

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Missiaen, L., Parys, J.B., De Smedt, H., Sienaert, I., Bootman, M.D., Casteels, R. (1996). Control of the Ca2+ Release Induced by myo-Inositol Trisphosphate and the Implication in Signal Transduction. In: Biswas, B.B., Biswas, S. (eds) myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction. Subcellular Biochemistry, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0343-5_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0343-5_3

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