Abstract
Matrix metalloproteinases (MMPs), also termed “matrixins”, constitute a family of zinc metalloendopeptidases that participate in breakdown of extracellular matrix macromolecules (Woessner, 1991). These enzymes are considered to play an important role in many biological processes such as in reproduction, embryogenesis, tissue resorption, and in the control of cell behavior. Overproduction of matrixins is associated with various connective tissue diseases such as arthritis, periodontitis, glomerulonephritis, tissue ulceration as well as being connected with tumor cell invasion and metastasis (Woessner, 1991; Birkedal-Hansen et al., 1993).
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© 1996 Plenum Press, New York
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Nagase, H. et al. (1996). Involvement of Tissue Inhibitors of Metalloproteinases (TIMPS) During Matrix Metalloproteinase Activation. In: Suzuki, K., Bond, J.S. (eds) Intracellular Protein Catabolism. Advances in Experimental Medicine and Biology, vol 389. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0335-0_3
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DOI: https://doi.org/10.1007/978-1-4613-0335-0_3
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