Abstract
Up to now diffusion limitation versus ventilation-perfusion inhomogeneities are in dispute as the main reason for impairing pulmonary gas exchange within interstitial lung diseases (Finley et al., 1962, Wagner et al., 1976, Jernudd-Wilhelmsson et al., 1986, Agusti et al., 1987, Hempleman and Hughes, 1991, Hughes et al., 1991, Yamaguchi et al., 1991). In order to assess pulmonary gas transport, such methods as the estimation of the arterial partial pressure of oxygen during nitrogen washout (Finley et al., 1962), the multiple inert gas elimination technique (Wagner et al., 1976, Jernudd-Wilhelmsson et al., 1986, Agusti et al., 1987, Hughes et al., 1991, Yamaguchi et al., 1991) and the determination of the single breath diffusing capacity for carbon monoxide (Finley et al., 1962, Wagner et al., 1976, Hughes et al., 1991) have been applied.
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References
Agusti, A.G.N., Roca, J., Rodriguez-Roisin, R., Gea, J., Xaubet, A., and Wagner, RD., 1987, Role of 02 diffusion limitation in idiopathic pulmonary fibrosis, Am. Rev. Respir. Dis. 135:A307.
Cotes, J. E., 1982, The.transfer factor (diffusing capacity), in “Standardized lung function testing” (Quanjer Ph. H., Editor), Report of the European Community for Coal and Steel, Luxembourg.
Feldman, D.E., Yost jr., H.T., and Benson, B.B., 1959, Oxygen isotope fractionation in reactions catalyzed by enzymes, Science, 129: 146–147.
Finley, T.N., Swenson, E.W., and Comroe, J.H., 1962, The cause of arterial hypoxemia at rest in patients with ‘alveolar-capillary block syndrome’, J. Clin. Invest., 41: 618–622.
Heller, H., Könen, M., and Schuster, K.-D., 1993, Dependence of overall fractionation effect of respiration on ventilation at rest, Isotopenpraxis 28:133–141.
Heller, H., Schuster, K.-D., and Göbel, B. O., 1994, Dependency of overall fractionation effect of respirationon hemoglobin concentration within blood at rest, Adv. Exp. Med. Biol. 345:755–761.
Hempleman, S.C., and Hughes, J.M.B., 1991, Estimating exercise DL02 and diffusion limitation in patients with interstitial fibrosis, Respir. Physiol., 83: 167–178.
Hughes, J.M.B., Lockwood, D.N.A., Jones, H.A., and Clark, R, J., 1991, DLCO/Q and diffusion limitation at rest and on exercise in patients with interstitial fibrosis, Respir. Physiol., 83: 155–166.
Jernudd-Wilhelmsson, Y, Hornblad, Y, and Hedenstierna, G., 1986, Ventilation-perfusion relationships in interstitial lung disease, Eur. J. Respir. Dis. 68:39–40.
Piiper, J., and Sikand, R.S., 1966, Determination of Dco by the single breath method in inhomogeneous lungs: theory, Respir. Physiol., 1: 75–87.
Piiper, J., 1992, Diffusion-perfusion inhomogeneity and alveolar-arterial 02 diffusion limitation: theory, Respir. Physiol. 87:349–356.
Quanjer, Ph.H., 1982, Standardized lung function testing, in: Working party “Standardization of lung function tests” of the European community for Coal and Steel, Ph.H. Quanjer, ed., Luxembourg.
Schuster, K.-D., Pflug, K.P., Forstel, H., and Pichotka, J.R, 1979, Adaptation of respiratory mass spectrometer to continuous recording of abundance ratios of stable oxygen isotopes, in: “Recent developments in mass spectrometry in biochemistry and medicine”, 2:451–462, A. Frigerio, ed., Plenum Publishing Corp., New York.
Schuster, K.-D., and Pflug, K.P., 1989, The overall fractionation effect of isotopie oxygen molecules during oxygen transport and utilization in humans, Adv. Exp. Med. Biol., 248: 151–156.
Schuster, K.-D. and Heller, H., 1994, Model analysis of oxygen isotope fractionation in humans due to disturbances of pulmonary gas exchange, Adv. Exp. Med. Biol, this volume.
Wagner, P.D., Dantzker, D.R., Dueck, R., dePolo, J.L., Wasserman, K., and West, J.B., 1976, Distribution of ventilation-perfusion ratios in patients with interstitial lung disease, Chest 69: 256–257.
Yamaguchi, K., Kawai, A., Mori, M., Asano, K., Takasugi, T., Umeda, A., Kawashiro, T., and Yokoyama, T., 1991, Distribution of ventilation and diffusing capacity to perfusion in the lung, Respir. Physiol. 86:171–187.
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© 1996 Plenum Press, New York
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Heller, H., Könen, M., Overlack, A., Schuster, K.D. (1996). Fractionation Effects of Oxygen Isotopes Within Interstitial Lung Disease. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_49
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DOI: https://doi.org/10.1007/978-1-4613-0333-6_49
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