Abstract
Tight regulation of cardiac oxidative phosphorylation to ensure fast and accurate adaptation to myocardial metabolic demand is of vital importance. There has been much discussion during the last decade on the nature of the signals that stimulate the mitochondria in the heart muscle to increase mitochondrial ATP synthesis when the workload to the heart is increased. The classic view is that ADP, the direct product of ATP hydrolysis, stimulates the mitochondria to increase ATP synthesis when muscle work increases. This is very likely correct in skeletal muscle but was challenged for cardiac muscle tissue (Balaban et al., 1986). Here we will review recent data that throw new light on this issue. We will particularly consider what happens in the first minute during the dynamic adaptation of ATP synthesis to a sudden change in workload to the heart.
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References
Ashruf, J.F., Coremans, J.M.C.C., Bruining, H.A., and Ince, C, 1995 Increase of cardiac work is associated with decrease of mitochondrial NADH in the Langendorff rat heart, Am. J. Physiol 269:H856–H862.
Balaban, R.S., 1990, Regulation of oxidative phosphorylation in the mammalian cell, Am. J. Physiol. 258:C377–C389.
Balaban, R.S., and Heineman, F.W., 1989, Interaction of oxidative phosphorylation and work in the heart, in vivo, News in Physiological Sciences 4:215–218.
Balaban, R.S., Kantor, H.L., Katz, L.A., and Briggs, R.W., 1986, Relation between work and phosphate metabolites and oxygen consumption in the in vivo paced mammalian heart, Science 232:1121–1123.
Beek, J.H.G.M. van, and Westerhof, N., 1991, Response time of cardiac mitochondrial oxygen consumption to heart rate steps, Am J. Physiol. 260: H613–H625.
Beek, J.H.G.M. van, Hak, J.B., and Eijgelshoven, M.H.J., 1992, Oxidative phosphorylation in the myocardium may be strongly stimulated by undetectably small changes in high-energy phosphates, Pflügers Arch. 420: R105.
Chance, B., 1965, The energy-linked reaction of calcium with mitochondria, J. Biol. Chem. 240: 2729–2748.
Chance, B., and Williams, G.R., 1956, The respiratory chain and oxidative phosphorylation, Adv. Enzymol. 17:65–134.
Eijgelshoven, M.H.J., Hak, J.B., Beek, J.H.G.M. van, and Westerhof, N., 1993, Adaptation speed of cardiac mitochondrial oxygen consumption decreases with higher heart rate, Am. J. Physiol. 265:H 1893–H1898.
Eijgelshoven, M.H.J., Beek, J.H.G.M. van, Mottet, I., Nederhoff, M.G.J., Echteid, C.J.A. van, and Westerhof, N., 1994, Cardiac high-energy phosphates adapt faster than oxygen consumption to changes in heart rate, Circ. Res. 75: 751–759.
Hak, J.B., Beek, J.H.G.M. van, Wijhe, M.H. van, and Westerhof, N., 1992, Influence of temperature on the response time of mitochondrial oxygen consumption in isolated rabbit heart, J. Physiol. (Lond) 447:17–31.
Hak, J.B., Beek, J.H.G.M. van, and Westerhof, N., 1993a, Acidosis slows the response of oxidative phosphorylation to metabolic demand in isolated rabbit heart, Pflügers Arch. 423:324–329.
Hak, J.B., Beek, J.H.G.M. van, Eijgelshoven, M.H. J., and Westerhof, N., 1993b, Mitochondrial dehydrogenase activity affects adaptation of cardiac oxygen consumption to demand, Am. J. Physiol. 264:H448–H453.
Hak, J.B., Beek, J.H.G.M. van, Wijhe, M.H. van, Eijgelshoven, M.H.J., and Westerhof, N., 1993c, Reduced cardiac ATP-synthetic capacity slows metabolic regulation and reduces contractility, In: J.B. Hak, Dynamics of Myocardial Oxidative Phosphorylation, Thesis, Vrije Universiteit, Amsterdam, the Netherlands. ISBN: 90-9005935-0.
Hak, J.B., Beek, J.H.G.M. van, Wijhe, M.H. van, and Westerhof, N., 1993d, Dynamics of myocardial lactate efflux after a step in heart rate in isolated rabbit heart, Am. J. Physiol. 265:H2081–H2085.
Harris, D.A, and Das, A.M., 1991, Control of mitochondrial ATP synthesis in the heart, Biochem. J. 280: 561–573.
Heineman, F.W, and Balaban, R.S., 1990, Phosphorus-31 nuclear magnetic resonance analysis of transient changes of canine myocardial metabolism in vivo, J. Clin. Invest. 85:843–852.
Heineman, F.W, and Balaban, R.S., 1993, Effects of afterload and heart rate on NAD(P)H redox state in the isolated rabbit heart., Am. J. Physiol. 264:H433–H440.
Heinrich, R., and Rapoport, T.A., 1975, Mathematical analysis of multienzyme systems: II. Steady state and transient control, Biosystems 7:130–136.
Kacser, H., and Burns, J.A., 1979, Molecular democracy: who shares the controls? Biochem. Soc. Trans. 7:1149–1160.
Kentish, J.C., 1986, The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle. J Physiol (Lond) 370:585–604.
Massie, B.M., Schwartz, G.G., Garcia, J., Wisnewki, J.A., Weiner, M.W., and Owens, T., 1994, Myocardial metabolism during increased work states in the porcine left ventricle in vivo, Circ. Res. 74:64–73.
Meyer, R.A., 1988, A linear model of muscle respiration explains monoexponential phosphocreatine changes, Am J.Physiol. 254:C548–C553.
Rooke, G.A., and Feigl, E.O., 1982, Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting, Circ. Res. 50:273–286.
Scholz, T.D., and Balaban, R.S., 1994, Mitochondrial Fl-ATPase activity of canine myocardium: effects of hypoxia and stimulation, Am J.Physiol. 266: H2396–H2403.
Suga, H., 1979, Total mechanical energy of a ventricle model and cardiac oxygen consumption, Am J.Physiol. 236: H498–H505.
Westerhoff, H.V., and Dam K. van, 1987, Thermodynamics and control of biological free-energy transduction, Elsevier, Amsterdam, the Netherlands, pp 162–186 and pp 436–494.
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© 1996 Plenum Press, New York
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van Beek, J.H.G.M., Tian, X. (1996). What Determines Cardiac Oxygen Consumption and How is it Regulated?. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_34
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DOI: https://doi.org/10.1007/978-1-4613-0333-6_34
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