Antibodies to von Willebrand factor in von Willebrand disease
The occurrence of an alloantibody directed against von Willebrand factor in a multitransfused patient with severe (type III) von Willebrand disease was first reported in 2 consecutive studies by Sarji et al. (1974) and Stratton et al. (1975). After this, 14 additional cases of alloantibodies were described and reviewed by Mannucci and Mari (1984). A survey carried out on behalf of the World Federation of Hemophilia identified 6 additional cases that, added to the 15 cases previously reported, bring to 21 the total number of patients reported so far with anti-von Willebrand factor alloantibodies (Mannucci and Cattaneo, 1991). In the frame of the survey, Hanna (1989) reported an antibody directed towards factor VIII (F.VIII) in a girl with severe von Willebrand disease. Since this antibody did not apparently react with von Willebrand factor, it will not be reviewed here.
KeywordsFactor VIII Bleeding Time Factor Viii Concentrate Multitransfused Patient Factor VIII Procoagulant
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