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Variable (V) region-mediated control of autoreactivity to factor VIII

  • Michel D. Kazatchkine
  • Srinivas S. Kaveri
  • Urs E. Nydegger
  • Yvette Sultan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)

Abstract

It is now recognized that autoreactive T and B cells are normally present in healthy individuals. Natural antibodies reactive with self-antigens are also present in normal serum and are frequent among hybridomas obtained from healthy individuals. Evidence accumulated in the last ten years indicates that autoreactivity is positively selected during ontogeny, that it provides the basis for an autonomous activity of the normal immune system independent of foreign antigens and that “physiological autoreactivity” is regulated within a network of interactions between variable (V) regions of antibodies and lymphocytes.1

Keywords

Factor VIII Autoimmune thyrOiditis Normal Human Serum Natural Antibody Antibody Repertoire 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • Michel D. Kazatchkine
    • 1
  • Srinivas S. Kaveri
    • 1
  • Urs E. Nydegger
    • 2
  • Yvette Sultan
    • 3
  1. 1.Service d’Immunologie and INSERM U28Hôpital BromsaisParisFrance
  2. 2.Center for Blood TransfusionInselspitalBernSwitzerland
  3. 3.Centre de Traitement des HemophilesHôpital CochinParisFrance

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