Immune tolerance to Factor VIII:The international registry data

  • G. Mariani
  • M. Hilgartner
  • A. R. Thompson
  • J. Tusell
  • M. Manco-Johnson
  • A. Ghirardini
  • R. Bellocco
  • H. H. Brackmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)


Among the problems related to the treatment of classic hemophilia, the presence of inhibitors (alloantibodies) to foreign Factor VIII (F.VIII) is one of the most serious. These antibodies may arise at any age, but the cumulative risk of developing an inhibitor one year after the first treatment with a factor concentrate is between 22% and 25%. 1,2The presence of such antibodies can render any further administration of F.VIII ineffective. On the basis of the speed and degree of immune response to F.VIII, patients have been divided into high- and low-responders.3This is an arbitrary classification, but it is related to important treatment characteristics. Low responders, that is patients whose maximum inhibitor titer is <10 Bethesda Units (B.U.), can be treated with F.VIII, albeit at higher doses; however, high-responders can seldom be treated with F.VIII and comprise the so-called “refractory hemophiliacs.”


Factor VIII Coagulation Factor Immune Tolerance Recombinant Factor VIII Factor Viii Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • G. Mariani
  • M. Hilgartner
  • A. R. Thompson
  • J. Tusell
  • M. Manco-Johnson
  • A. Ghirardini
  • R. Bellocco
  • H. H. Brackmann

There are no affiliations available

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