The Antihistamine Action of Ascorbic Acid

Part of the Subcellular Biochemistry book series (SCBI, volume 25)


Histamine is a critical messenger molecule in times of stress, promoting alertness, blood flow, and healing (Kahlson et al., 1960; Schayer, 1962; White and Rumbold, 1988). Excess histamine, however, has a negative impact on circulatory and immunologic homeostasis (Schayer, 1962; Falus and Merétey, 1992) and aggravates inflammatory conditions of the gut (Rangachari, 1992) and respiratory tract (Doyle et al., 1994). Thus, antihistamine therapy is used for systematic treatment of certain diseases, including acid-peptic disorders (Feldman and Burton, 1990b), allergy (howarth, 1983; Schata et al., 1991; Naclerio, 1993), and inflammatory skin disorders (Giacosa et al.,1978).


Mast Cell Histamine Release Plasma Vitamin Histamine Level Neutrophil Chemotaxis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



adenosine monophosphate


cyclic guanine monophosphate

Con A

concanavalin A


diamine oxidase


antibody crystallizable fragment


forced expiratory volume


histidine receptor 1


histidine carboxylase


histamine forming capacity




high-performance liquid chromatography


histamine releasing factor


histamine-induced suppressor factor


immunnoglobulin E






low-density lipoprotein


maximal expiratory flow


major histocompatibility complex


migration inhibition factor


nuclear magnetic resonance


osteogenic disorder Shionogi


platelet activating factor


uridine diphosphate


very low density lipoprotein.


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© Plenum Press, New York 1996

Authors and Affiliations

  1. 1.Department of Family Resources and Human DevelopmentArizona State UniversityTempeUSA

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