The Antihistamine Action of Ascorbic Acid

  • Carol S. Johnston
Part of the Subcellular Biochemistry book series (SCBI, volume 25)

Abstract

Histamine is a critical messenger molecule in times of stress, promoting alertness, blood flow, and healing (Kahlson et al., 1960; Schayer, 1962; White and Rumbold, 1988). Excess histamine, however, has a negative impact on circulatory and immunologic homeostasis (Schayer, 1962; Falus and Merétey, 1992) and aggravates inflammatory conditions of the gut (Rangachari, 1992) and respiratory tract (Doyle et al., 1994). Thus, antihistamine therapy is used for systematic treatment of certain diseases, including acid-peptic disorders (Feldman and Burton, 1990b), allergy (howarth, 1983; Schata et al., 1991; Naclerio, 1993), and inflammatory skin disorders (Giacosa et al.,1978).

Keywords

Placebo Psoriasis Catecholamine Rhinitis Inositol 

Abbreviations

AMP

adenosine monophosphate

cGMP

cyclic guanine monophosphate

Con A

concanavalin A

DAO

diamine oxidase

Fc

antibody crystallizable fragment

FEV

forced expiratory volume

H1

histidine receptor 1

HDC

histidine carboxylase

HFC

histamine forming capacity

HMT

histamine-N-methyltransferase

HPLC

high-performance liquid chromatography

HRF

histamine releasing factor

HSF

histamine-induced suppressor factor

IgE

immunnoglobulin E

IL-1

interleukin-1

INF

interferon

LDL

low-density lipoprotein

MEF

maximal expiratory flow

MHC

major histocompatibility complex

MIF

migration inhibition factor

NMR

nuclear magnetic resonance

ODS

osteogenic disorder Shionogi

PAF

platelet activating factor

UDP

uridine diphosphate

VLDL

very low density lipoprotein.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Carol S. Johnston
    • 1
  1. 1.Department of Family Resources and Human DevelopmentArizona State UniversityTempeUSA

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