Propeptide-Mediated Folding in Subtilisin: The Intramolecular Chaperone Concept

  • Ujwal Shinde
  • Masayori Inouye
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 379)


Subtilisin, an alkaline serine protease consisting of 275 amino acid residues is produced in various strains of Bacillus 1. As it was first identified in B. subtilis the enzyme was named ‘subtilisin’. Different variants of this enzyme have been identified and well studied. Among these include subtilisin BPN’, subtilisin E and subtilisin Carlsberg. Later this exoenzyme was found to belong to a very large family of proteins spanning both prokaryotes and eukaryotes called subtilases2.


Mature Region Alkaline Serine Protease Robert Wood Johnson Medical School Subtilisin Family OmpA Signal 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Ujwal Shinde
    • 1
  • Masayori Inouye
    • 1
  1. 1.Department of BiochemistryUniversity of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical SchoolPiscatawayUSA

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