Binary and Sparse Checkerboard Visual Stimuli in Multiple Sclerosis Patients

  • Rasa Ruseckaite
  • Teddy Maddess
  • Andrew Charles James
Part of the Biocomputing book series (BCOM, volume 2)


Visual evoked potentials (VEPs) to checkerboard stimuli are often recorded to evaluate the functional visual nervous system from the eye to brain. For example, various types of VEPs have been used for the early detection of multiple sclerosis (MS) [Harter, 1970,Chiappa, 1983,Andersson and Siden, 1991,Towle et al., 1991, Hood and Zhang, 2000]. MS is a central nervous system (CNS) disease, characterized by multiple areas of demyelination [Robinson and Rudge, 1977, Waxman, 1983]. People suffering from MS often develop optic neuritis (ON) as well.


Multiple Sclerosis Patient Video Frame Optic Neuritis Pattern Pulse Multiple Sclerosis Subject 
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  1. [Andersson and Siden, 1991]
    Andersson, T. and Siden, A. (1991). Multi-modality evoked potentials and neurological phenomenology in patients with multiple sclerosis and potentially related conditions. Electromyogr Clin Neurophysiol, 31: 109–117.Google Scholar
  2. [Chiappa, 1983]
    Chiappa, K. (1983). Evoked potentials in clinical medicine, chapter Pattern shift visual evoked potentials: interpretation, pages 63–104. Raven Press, New York.Google Scholar
  3. [Harter, 1970]
    Harter, M. (1970). Evoked cortical responses to checkerboard patterns: effect of check-size as a function of retinal eccentricity. Vision Res, 10: 1365–1376.CrossRefGoogle Scholar
  4. [Hood et al., 2000a]
    Hood, D., Odel, J., and Zhang, X. (2000a). Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP study. Invest Ophthalmol Vis Sci, 41: 4032–4038.Google Scholar
  5. [Hood and Zhang, 2000]
    Hood, D. and Zhang, X. (2000). Multifocal ERG and VEP responses and visual fields: comparing disease - related changes. Doc Ophthalmol, 100: 115–137.CrossRefGoogle Scholar
  6. [Hood et al., 2000b]
    Hood, D., Zhang, X., Greenstein, V., Kangovi, S., Odel, J., Liebmann, M., and Ritch, R. (2000b). An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve. Invest Ophthalmol Vis Sci, 41: 1580–1587.Google Scholar
  7. [James, 2003]
    James, A. (2003).The pattern pulse multifocal visual evoked potential. Invest Ophtalmol Vis Sci, (in press).Google Scholar
  8. [Johnson and Wichern, 1992]
    Johnson, R. and Wichern, D. (1992). Applied multivariate statistical analysis. Prentice-Hall, Inc., third edition.MATHGoogle Scholar
  9. [Johnson and Wichern, 1992]
    Johnson, R. and Wichern, D. (1992). Applied multivariate statistical analysis. Prentice-Hall, Inc., third edition.MATHGoogle Scholar
  10. [Maddess et al., 2003]
    Maddess, T., Ruseckaite, R., and James, A. (2003).Effect of temporal sparsensee and dichoptic presentation upon multifocal visual evoked potential. J Neurosci, (in press).Google Scholar
  11. [Robinson and Rudge, 1977]
    Robinson, K. and Rudge, P. (1977). Abnormalities of the auditory evoked potentials in patients with multiple sclerosis. Brain, 100: 19–40.CrossRefGoogle Scholar
  12. [Towle et al., 1991]
    Towle, V., Witt, J., Nader, S., Reder, A., Foust, R., and Spire, J. (1991). Three-dimensional human pattern visual evoked potentials. ii. multiple sclerosis patients. Electroencephalogr Clin Neurophysiol, 80: 339–346.CrossRefGoogle Scholar
  13. [Waxman, 1983]
    Waxman, S. (1983). The demyelinating diseases. Clinical Neurosc, 1: 609–643.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Rasa Ruseckaite
    • 1
  • Teddy Maddess
    • 1
  • Andrew Charles James
    • 1
  1. 1.Centre for Visual Sciences Research School of Biological SciencesAustralian National UniversityCanberraAustralia

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