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Xenobiotic Impacts on the Skeletal System of Teleosts

  • Daniel J. Karen
  • Philippe E. Ross
  • Stephen J. Klaine
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 172)

Abstract

The nervous and endocrine systems form closely related structures throughout the vertebrate body. For example, cholinergic and adrenergic neurons can affect hypothalamic signaling of the pituitary and modulate the hormonal axes governed by hypothalamic signals. Interfering with neuronal signal propagation on the neuron or at the synapse can therefore have serious implications regarding the health and well-being of affected organisms by disrupting normal neuroendocrine control of many homeostatic processes. Anthropogenic compounds, specifically organophosphate agents such as chlorpyrifos, have this potential. Ultimately, neurological changes or neuroendocrine disruption may alter skeletal structural integrity. Other xenobiotics, like organochlorines, may disrupt normal metabolic processes. Altered metabolic pathways may affect the composition of the skeletal system. Therefore, exposure to organophosphate and organochlorine pesticides may elicit changes in mechanical properties and composition of bone. In teleost fish, these effects have been observed in the field and reproduced in the laboratory.

Keywords

Brook Trout Skeletal System Plasma Calcium Fathead Minnow Fundulus Heteroclitus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Daniel J. Karen
    • 1
  • Philippe E. Ross
    • 2
  • Stephen J. Klaine
    • 3
  1. 1.ARCADIS JSALong BeachUSA
  2. 2.Environmental Engineering and ScienceColorado School of MinesGoldenUSA
  3. 3.Department of Environmental ToxicologyClemson UniversityPendletonUSA

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