Abstract
Proliferating cells go through a regular cycle of events, the mitotic cell cycle, in which the genetic material is duplicated and divided equally between two daughter cells. This is brought about by the duplication of each chromosome to form two closely adjacent sister chromatids, which separate from each other to become two daughter chromosomes. These, along with the other chromosomes of each set, are then packaged into two genetically identical daughter nuclei. The molecular mechanisms underlying the cell cycle are highly conserved in all organisms with a nucleus (eukaryotes). Many of the genes and proteins involved in the human cell cycle have been identified because of their high degree of nucleotide and amino acid sequence similarity to homologous genes and proteins in the more easily studied budding yeast, Saccharomyces cerevisiae, in which the cell cycle is more fully understood.
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© 2001 Springer Science+Business Media New York
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Miller, O.J., Therman, E. (2001). The Mitotic Cell Cycle. In: Human Chromosomes. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-0139-4_2
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DOI: https://doi.org/10.1007/978-1-4613-0139-4_2
Publisher Name: Springer, New York, NY
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