Abstract
The expectation that oxygen might improve the ailing patient is nearly as old as the discovery of oxygen itself. The belief that his newly found “dephlogisticated air” would be of medical benefit was recorded by Joseph Priestly after the meager trial of being sampled by two mice and himself [35]. John Hunter proposed its use for resusciation in 1776 [21]. Since then, the desire to get more oxygen into patients has been pursued with great vigor, even though its pulmonary toxicity had been noted in the literature (albeit in mice) by 1796 [4]. Since then, the methodology, understanding, and limitations of getting more oxygen to the tissues have been, in large part, worked out. Now the problems of oxygen delivery have become so seemingly trivial that they are prematurely being treated with indifference by those who fund research programs. This will continue unless something dramatic is offered, such as extracorporeal oxygenation.
“Anoxaemia not only stops the machine but wrecks the machinery.”
J. S. Haldane
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Bryan-Brown, C.W. (1978). Tissue Blood Flow and Oxygen Transport in Critically Ill Patients. In: Critical Care Medicine Manual. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9932-5_26
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DOI: https://doi.org/10.1007/978-1-4612-9932-5_26
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