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Techniques for Establishing Appropriate Dose Regimens of Digitalis

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Critical Care Medicine Manual

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Abstract

Much recent attention has been directed to the problem of bioavailability. While oral digitoxin appears to be essentially completely absorbed [28], the bioavailability of oral digoxin appears to be somewhere between 85% [3–5] and 50% [7]. Other digoxin preparations may be even less well absorbed. Because of this, parenteral doses of digoxin probably should be reduced to 50–85% of the corresponding oral dose when using oral digoxin of good bioavailability, while little or no such reduction appears necessary for digitoxin.

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Authors and Affiliations

  1. University of Southern California, School of Medicine, Los Angeles, California, USA

    Roger W. Jelliffe M.D. (Associate Professor of Medicine)

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  1. Roger W. Jelliffe M.D.
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© 1978 Springer-Verlag New York Inc.

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Jelliffe, R.W. (1978). Techniques for Establishing Appropriate Dose Regimens of Digitalis. In: Critical Care Medicine Manual. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9932-5_25

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  • DOI: https://doi.org/10.1007/978-1-4612-9932-5_25

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9934-9

  • Online ISBN: 978-1-4612-9932-5

  • eBook Packages: Springer Book Archive

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