Discussion/Chapters 16–17

  • Volker ter Meulen
  • Michael Katz
Conference paper


Dr. Koprowski expressed concern that so much work on the defective viruses has been carried out in vesicular stomatitis virus, which is so highly virulent. He voiced doubts that defective, interfering particles played a significant role in multiple sclerosis (MS). He felt, however, that the question of temperature-sensitive mutants and the types of mutants described by Dr. Choppin may play a larger role in the development of chronic neurologic diseases. Dr. Gajdusek added that a search for temperature-sensitive mutants in spongiform encephalopathies, conducted in his and Dr. Gibbs’ laboratories, has been unsuccessful.


Multiple Sclerosis Temperature Sensitivity Persistent Infection Vesicular Stomatitis Virus Virus Mutant 
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Volker ter Meulen
    • 1
  • Michael Katz
    • 2
  1. 1.Institut fuer VirologieWuerzburgWest Germany
  2. 2.College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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