Carbon Dioxide in Cerebral Extracellular Fluids

  • Vladimir Fencl
Conference paper
Part of the Topics In Environmental Physiology And Medicine book series (TEPHY)


The extravascular extracellular compartment of the cerebral fluids consists of the cerebral interstitial fluid (cISF) and of the cerebrospinal fluid (CSF). Both these fluids are continuously formed from, and returned to, the blood plasma (DAVSON [1967]). The rate of formation and bulk absorption of CSF is slow, about 0.5% of its total volume per minute (HEISEY et al. [1962]). In cISF the turnover is probably faster (FENCL et al. [1966]). CSF in the ventricles is separated from cISF by the ependyma; on the outer surface of the brain the separation between CSF and cISF is formed by pia-glia. Both these boundaries permit exchange by free diffusion of even large molecules, between cISF and the CSF in large cerebral cavities (BRIGHTMAN et al. [1970]).


Cerebral Blood Flow Metabolic Acidosis Arterial Plasma Plasma Bicarbonate Chronic Metabolic Acidosis 
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Copyright information

© Springer-Verlag New York Inc. 1974

Authors and Affiliations

  • Vladimir Fencl
    • 1
  1. 1.Department of PhysiologyHarvard Medical SchoolBostonUSA

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