Pathology of the Umbilical Cord and Major Fetal Vessels. Vestiges of Embryonic Structures

  • Kurt Benirschke
  • Shirley G. Driscoll

Abstract

In grouping the pathologic changes of the major fetal vessels together with the pathology of the umbilical cord it is recognized that their development and structure is intimately related. Moreover, an abnormal condition in one, e. g. excessively long cord, is often associated with pathologic events in the other e. g. thrombosis of vessels, and these events are frequently causally related.

Keywords

Assure Norepinephrine Vasculitis Liquefaction Thalidomide 

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References

  1. Adler, J., H. Leventhal & N. Ben-adereth: Absence of one umbilical artery and its relationship to congenital malformations. Harefuah 65, 286, 1963.PubMedGoogle Scholar
  2. Arts, N. F. Th.: Investigations on the vascular system of the placenta. I. General introduction and the fetal vascular system. Amer. J. Obstet. Gynec. 82, 147, 1961.PubMedGoogle Scholar
  3. Bacsich, P. & J. M. Crawford: On the probable genetic character of human placental types, with some remarks on the structure of placental cotyledons. J. Anat. 94, 449, 1960.Google Scholar
  4. Bacsich, P. & W. J. B. Riddell: Structure and nutrition of the cornea, cartilage and Wharton’s jelly. Nature 155, 271, 1945.Google Scholar
  5. Bacsich, P. & C. F. Y. Smotjt: Some observations on the foetal vessels of the human placenta with an account of the corrosion technique. J. Anat. 72, 358, 1938.PubMedGoogle Scholar
  6. Ballantyne, J. W.: The occurrence of a nonallantoic or vitelline placenta in the human subject. Trans. Edinburgh Obstet. Soc. 23, 58, 1898.Google Scholar
  7. Barden, T. P. & R. W. Stander: Intrauterine pressure and fetal heart rate in labor. J.A.M.A. 186, 923, 1963.PubMedGoogle Scholar
  8. Barry, F. E., C. P. Moy & W. P. Callahan: Hemangioma of the umbilical cord. Amer. J. Obstet. Gynec. 62, 675, 1951.PubMedGoogle Scholar
  9. Becker, Y.: Funktionelle Morphologie der Placenta. Arch. Gynäk. 198, 3, 1963.Google Scholar
  10. — & D. Dolling: Gefäßverschlüsse in der Placenta von Totgeborenen. Yireh. Arch, path. Anat. 338, 305, 1965.Google Scholar
  11. Benirschke, K.: A review of the pathologic anatomy of the human placenta. Amer. J. Obstet. Gynec. 84, 1595, 1962.PubMedGoogle Scholar
  12. — Major pathologic features of the placenta, cord and membranes. Proceed. Symposium on the placenta. National Foundation N.Y. 1, 52, 1965.Google Scholar
  13. Benirschke, K. & G. L. Bourne: The incidence and prognostic implication of congenital absence of one umbilical artery. Amer. J. Obstet. Gynec. 79, 251, 1960.PubMedGoogle Scholar
  14. Benirschke, K. & W. H. Brown: A vascular anomaly of the umbilical cord. The absence of one umbilical artery in the umbilical cords of normal and abnormal fetuses. Obstet. Gynec. 6, 399, 1955.PubMedGoogle Scholar
  15. Benirschke, K., M. M. Sullivan & M. Marin-padilla: Size and number of umbilical vessels. A study of multiple pregnancy in man and armadillo. Obstet. Gynec 24, 819, 1964.PubMedGoogle Scholar
  16. Ten Berge, B. S.: Nervenelemente in Plazenta und Nabelschnur. Gynaeeologia 156, 49, 1963.Google Scholar
  17. Bergman, P., P. Lundin & T. Malmström: Mucoid degeneration of Wharton’s jelly. An umbilical cord anomaly threatening foetal life. Acta Obst. Gynec. Scand. 40, 372, 1961.Google Scholar
  18. Blanc, W. A.: Aplasia of one umbilical artery. Personal communication, 1963Google Scholar
  19. Froehlich, L. A. & Fujikura, T.: Significance of single umbilical artery. A report from the collaborative study of c erebral palsy. Amer. J. Obstet. Gynec. 94, 274,1966).PubMedGoogle Scholar
  20. Blanc, W. A. & G. W. Allan: Intrafunieular ulceration of persistent omphalomesenteric duct with intra-amniotic hemorrhage and fetal death. Amer. J. Obstet. Gynec. 82, 1392, 1961.PubMedGoogle Scholar
  21. Bøe, F.: Yascular morphology of the human placenta. In: Cold spring harbor symposia on quantitative biology. 19, 29, 1954.PubMedGoogle Scholar
  22. Bourne, G. L.: The human amnion and chorion. Lloyd-Luke, London 1962.Google Scholar
  23. Bourne, G. L. & K. Benirschke: Absent umbilical artery. A review of 113 cases. Arch. Dis. Child. 35, 534, 1960.PubMedGoogle Scholar
  24. Broman, I.: Normale und Abnorme Entwicklung des Menschen. (Ein Hand- und Lehrbuch der Ontogenie und Teratologie.) J. F. Bergmann, Wiesbaden 1911.Google Scholar
  25. Browne, F. J.: On the abnormalities of the umbilical cord which may cause antenatal death. J. Obstet. Gynaee. Brit. Emp. 32, 17, 1925.Google Scholar
  26. Cairns, J. D. & J. Mee: Single umbilical artery: a prospective study of 2,000 consecutive deliveries. Canad. Med. Ass. J. 91, 1071, 1964.PubMedGoogle Scholar
  27. Clarke, J. A.: An x-ray microscopic study of the vasa vasorum of the human umbilical arteries. Z. Zellf. 66, 293, 1965.Google Scholar
  28. Clendenin, T. M. & K. Benirschke: Chromosome studies on spontaneous abortions. Lab. Invest. 12: 1281, 1963.PubMedGoogle Scholar
  29. Corhill, T. F.: Infant’s vulnerable life line. Austral. New Zeal. J. Obstet. Gynec. 1, 154, 1961.Google Scholar
  30. Crawford, J. S.: Cord around the neck: further analysis of incidence. Acta Paediat. 53, 553, 1964.Google Scholar
  31. Cullen, T. S.: Embryology, anatomy, and disease of the umbilicus together with diseases of the urachus. W. B. Saunders, Philadelphia 1916.Google Scholar
  32. Davignon, J. & J. T. Shepherd: Response of the human umbilical artery “in vitro” to changes in transmural pressure. Federation Proc. 23, I No. 2, 309, Abstract 1250. 1964.Google Scholar
  33. Dippel, A. L.: Hematomas of the umbilical cord. Surg. Gynec. Obstet. 70, 51, 1940.Google Scholar
  34. — Maligned umbilical cord entanglements. Amer. J. Obstet. Gynec. 88, 1012, 1964.PubMedGoogle Scholar
  35. Dunn, P. M., A. M. Fisher & H. G. Köhler: Phocomelia. Amer. J. Obstet. Gynec. 84, 348, 1962.Google Scholar
  36. Earn, A. A.: The effect of congenital abnormalities of the umbilical cord and placenta on the newborn and mother. A survey of 5676 consecutive deliveries. J. Obstet. Gynaec. Brit. Emp. 58, 456, 1951.PubMedGoogle Scholar
  37. Eastman, N. J. & L. M., Hellman Eds.: Williams Obstetrics (ed, 12) Appleton, New York, 1961.Google Scholar
  38. Eternod, A. C. F.: L’Oeuf humain. Georg & Cie. Geneva, 1909.Google Scholar
  39. Faierman, E.: The significance of one umbilical artery. Arch. Dis. Child. 35, 285, 1960.PubMedGoogle Scholar
  40. Feingold, M., R. N. Fine & D. Ingall: Intravenous pyelography in infants with single umbilical artery. A preliminary report. New Eng. J. Med. 270, 1178, 1964.Google Scholar
  41. Finley, W. H., S. C. Finley & E. T. Carte: 17–18 trisomy syndrome. Review and report of a case. Amer. J. Dis. Child. 106, 591, 1963.PubMedGoogle Scholar
  42. Fischer, A.: Fetale Atrophie bei fehlerhafter Anlage der Nabelarterien und Kleinheit der Placenta; ein Beitrag zur Frage nichterblicher Mißbildungen. Frankf. Z. Path. 68, 497, 1957.Google Scholar
  43. Foldes, J. J.: Spontaneous intrauterine rupture of the umbilical cord. Obstet. Gynec. 9, 608, 1957.PubMedGoogle Scholar
  44. v. Franqué, O.: Anatomische und klinische Beobachtungen über Plaeentarerkrankungen. Z. Geburtsh. Gynäk. 28, 147, 1894.Google Scholar
  45. — Über histologische Veränderungen in der Placenta und ihre Beziehungen zum Tode der Frucht. Z. Geburtsh. Gynäk. 37, 277, 1897.Google Scholar
  46. Fujikura, T.: Single umbilical artery and congenital malformations. Amer. J. Obstet. Gynec. 88, 829, 1964.Google Scholar
  47. Gardner, R. F. R. & R. R. Trussel: Ruptured hematoma of the umbilical cord. Obstet. Gynec. 24, 791, 1964.PubMedGoogle Scholar
  48. German, J. L., 3d., J. K. Rankin, P. A. Harrison, D. J. Donovan, W. J. Hogan & A. G. Bearn: Autosomal trisomy of a group 16–18 chromosome. J. Pediat. 60, 503, 1962.Google Scholar
  49. Gisel, A.: Persistenz der Arteria omphalomesaraica und Fehlen der Nabelarterien bei einem Neugeborenen. Ein Beitrag zur Lehre von der Kombination und Korrelation anatomischer Varietäten. Z. Anat. Entw. gesch. 108, 686, 1938.Google Scholar
  50. Gömöri, Z. & Th. Koller: Über das Fehlen einer Arterie in der Nabelschnur. Gynaecologia 157, 177, 1964.Google Scholar
  51. Grosser, O.: Frühentwicklung, Eihautbildung und Placentation des Menschen und der Säugetiere. J. F. Bergmann, München 1927.Google Scholar
  52. Gruenwald, P.: Abnormalities of placental vascularity in relation to intrauterine deprivation and retardation of fetal growth. Significance of avascular chorionic villi. New York J. Med. 61, 1508, 1961.Google Scholar
  53. — Chronic fetal distress and placental insufficiency. Biol. Neonat. 5, 215, 1963.PubMedGoogle Scholar
  54. —, & H. W. Mayberger: Differences in abnormal development of monozygotic twins. Arch. Path. 70, 685, 1960.PubMedGoogle Scholar
  55. Gustavson, K.–H.: Down’s syndrome. A clinical and cytogenetical investigation, (p. 88, 95). Almqvist & Wiksells, Uppsala 1964.Google Scholar
  56. —, S. C. Finley, W. H. Finley & B. Jalling: A 4–5/21–22 chromosomal translocation associated with multiple congenital anomalies. Acta Paediat. 53, 172, 1964.Google Scholar
  57. Hall, S. P.: The thin-cord syndrome. A review with a report of two cases. Obstet. Gynec. 18, 507, 1961.PubMedGoogle Scholar
  58. Harris, L. E. & J. E. Wenzl: Heterotopic pancreatic tissue and intestinal mucosa in the umbilical cord. Report of a case. New Engl. J. Med. 268, 721, 1963.Google Scholar
  59. Hartmann, H.: Zur Kasuistik der Plaeentargefäßanomalien. Varicenbildung der Placentarvenen. Zbl. Gynäk. 53, 1233, 1929 quoted by Scipiades & Burg.Google Scholar
  60. Hecht, F.: The placenta in trisomy 18 syndrome. Report of 2 cases. Obstet. Gynec. 22, 147, 1963.PubMedGoogle Scholar
  61. Hertig, A. T.: The placenta: Some new knowledge about an old organ. Obstet. Gynec. 20, 859, 1962.PubMedGoogle Scholar
  62. —, and J. Rock: Two human ova of the pre-villous stage, having an ovulation age of about eleven and twelve days respectively. Carnegie Inst. Wash. Pub. 525, Contrib. to Embryol. No. 184 Vol. 29, 127, 1941.Google Scholar
  63. Hörmann, G.: Zur Systematik einer Pathologie der menschlichen Placenta. Arch. Gynäk. 191, 297, 1958.Google Scholar
  64. Hong, C. Y. & M. A. Simon: Amniotic bands knotted about umbilical cord. A rare cause of fetal death. Obstet. Gynec. 22, 667, 1963.PubMedGoogle Scholar
  65. Hyber, C. P., J. E. Carter & F. Vellios: Lesions of the circulatory system of the placenta. A study of 234 placentas with special reference to the development of infarcts. Amer. J. Obstet. Gynec. 81, 560, 1961.Google Scholar
  66. Hyrtl, J.: Die Blutgefäße der menschlichen Nachgeburt in normalen und abnormen Verhältnissen. Braumüller, Wien 1870.Google Scholar
  67. Irani, P. K.: Haematoma of the umbilical cord. Brit. Med. J. ii, 1436, 1964.Google Scholar
  68. Ivemark, B. I., C. Lagergren & A. Ljungqvist: Generalized arterial calcification associated with hydramnios in two stillborn infants. Acta Paediat. 51, (Suppl. 135): 103, 1962.Google Scholar
  69. Javert, C. T.: Spontaneous and habitual abortion. New York, Blakiston Division, 1957.Google Scholar
  70. —, & B. Barton: Congenital and acquired lesions of the umbilical cord and spontaneous abortion. Amer. J. Obstet. Gynec. 63, 1065, 1952.PubMedGoogle Scholar
  71. Kajii, T., M. Shinohara, K. Kikuchi, S. Dohmen & M. Akichika: Thalidomide and the umbilical artery. Lancet 11, 889, 1963.Google Scholar
  72. Kalter, H. & J. Warkany: Experimental production of malformations in strains of inbred mice by maternal treatment with hypervitaminosis A. Amer. J. Path. 38, 1, 1961.PubMedGoogle Scholar
  73. Kampmeier, O. F.: On sireniform monsters, with a consideration of the causation and the predominance of the male sex among them. Anat. Rec. 34, 365, 1927.Google Scholar
  74. Kan, P. S. & N. J. Eastman: Coiling of the umbilical cord around the foetal neck. J. Obstet. Gynaec. Brit. Emp. 64, 227, 1957.Google Scholar
  75. Kessler, A.: Blutungen aus Nabelschnurgefäßen in der Schwangerschaft. Gynaeeolo– gia 150, 353, 1960.Google Scholar
  76. King, E. L.: Intrauterine death of the fetus due to abnormalities of the umbilical cord. Amer. J. Obstet. Gynec. 12, 812, 1926.Google Scholar
  77. Kotz, H. L. & R. A. Yidone: Intrauterine fetal death due to amniotic bands; a review of the literature and case report. Obstet. Gynec. 13, 717, 1959.PubMedGoogle Scholar
  78. Kreyberg, L.: A teratoma-like swelling in the umbilical cord possibly of acardius nature. J. Path. Bact. 75, 109, 1958.PubMedGoogle Scholar
  79. Krone, H. A.: Die Bedeutung der Eibettstörungen für die Entstehung menschlicher Mißbildungen. G. Fischer, Stuttgart 1961.Google Scholar
  80. Lee, S. T. & E. H. Hon: Fetal hemodynamic response to umbilical cord compression. Obstet. Gynec. 22, 553, 1963.PubMedGoogle Scholar
  81. Leff, M.: Hemorrhage from a ruptured varicosity in the placenta causing the death of the fetus. Amer. J. Obstet. Gynec. 22, 117, 1931.Google Scholar
  82. Lenoski, E. F. & H. Medovy: Single umbilical artery: Incidence, clinical significance and relation to autosomal trisomy. Canad. Med. Ass. J. 87, 1229, 1962.PubMedGoogle Scholar
  83. Levina, M. J.: Alters Veränderungen der Whartonsehen Sülze der Nabelschnur des Menschen. (Russ.) Dokl. Akad. Nauk. SSSR N. S. 77, 109, 1951.Google Scholar
  84. Lewis, A. J.: Autosomal trisomy. Lancet i, 866, 1962.Google Scholar
  85. Little, A.: Aplasia of the umbilical artery. Bull. Sloane Hosp. Worn. 4, 127, 1958.Google Scholar
  86. Little, W. A.: Umbilical artery aplasia. Obstet. Gynec. 17, 695, 1961.PubMedGoogle Scholar
  87. Lyon, F. A.: Fetal abnormalities associated with umbilical cords containing one umbilical artery and one umbilical vein. Obstet. Gyneq. 16, 719, 1960.Google Scholar
  88. Mckay, D. G., C. C. Roby, A. T. Heutig & M. Y. Richardson: Studies of the function of early human trophoblast. II. Preliminary observations on certain chemical constituents of chorionic and early amniotic fluid. Amer. J. Obstet. Gynec. 69, 735, 1955.PubMedGoogle Scholar
  89. Majer, F. T.: De foetu humano monopodio. Diss. Inaug. Tubingae 1827, L. F. Fues; quoted by Ballantyne.Google Scholar
  90. Malpas, P.: Length of the human umbilical cord at term. Brit. Med. J. 1, 673, 1964.PubMedGoogle Scholar
  91. Merttens, J.: Beiträge zur normalen und pathologischen Anatomie der menschlichen Placenta. Z. Geburtsh. Gynäk. 30, 1, 1894.Google Scholar
  92. Meyer, A. W.: On the structure of the human umbilical vesicle. Amer. J. Anat. 3, 155, 1904.Google Scholar
  93. Meyer, R.: Mola hydatiformis (Blasenmole) und Chorionepithelioma malignum uteri. Handb. Spez. Path. Anat. Hist. VII/I: Springer, Berlin 1930.Google Scholar
  94. Miller, J. Q., E. H. Picard, M. K. Al.kan, S. Warner & P. S. Gerald: A specific congenital brain defect (arhinencephaly) in 13–15 trisomy. New Engl. J. Med. 268, 120, 1963.Google Scholar
  95. Molz, G.: Aplasie einer Nabelarterie und angeborene Fehlbildungen. Helvet. Paediat. Acta 20, 403, 1965.PubMedGoogle Scholar
  96. Moore, R. D.: Mast cells of the human umbilical cord. Amer. J. Path. 32, 1179, 1956.PubMedGoogle Scholar
  97. Nesbitt, R. E. L.: Perinatal loss in modern obstetrics. Davis Co., Philadelphia 1957.Google Scholar
  98. Panigel, M.: Réactions vaso-motrices de l’arbre vasculaire foetal au cours de cotylédons placentaires isolés maintenus en survie. Compt. Rend. Sc. Acad. Sci. 255, 3238, 1962.Google Scholar
  99. Papadatos, C. & A. Paschos: Single umbilical artery and congenital malformations. Obstet. Gynec. 26, 367, 1965.PubMedGoogle Scholar
  100. Peckham, C. H. & J. Yerushalmy: Aplasia of one umbilical artery: Incidence by race and certain obstetric factors. Obstet. Gynec. 26, 359, 1965.PubMedGoogle Scholar
  101. Potter, E. L.: Pathology of the fetus and infant. Year book medical publishers, Chicago 1961.Google Scholar
  102. Priman, J.: A note on the anastomosis of the umbilical arteries. Anat. Ree. 134, 1,1959.Google Scholar
  103. Raunenberg, E.: Zbl. Gynäk. 48, 30, 1924, quoted by Leff.Google Scholar
  104. Reynolds, S. R. M.: The proportion of Wharton’s jelly in the umbilical cord in relation to distention of the umbilical arteries and vein, with observations on the folds of Hoboken. Anat. Ree. 113, 365, 1952.Google Scholar
  105. Rhen, K. & O. Kinnunen: Ante-partum rupture of the umbilical cord. Acta Obstet. Gynec. Scand. 41, 86, 1962.PubMedGoogle Scholar
  106. Richart, R. & K. Benirschke: Gonadal dysgenesis in a newborn infant. New Engl. J. Med. 258, 974, 1958.Google Scholar
  107. Rissmann: Aneurysma der Nabelschnurarterie. Zbl. Gynäk. No. 9, 1931, quoted by Fischer.Google Scholar
  108. Roberge, J. L.: Sympodia in identical twins. J.A.M.A. 186, 728, 1963.PubMedGoogle Scholar
  109. Russell, C. S. & M. D. Mckichan: Thalidomide and congenital abnormalities. Lancet 1, 429, 1962.Google Scholar
  110. Rust, W.: Seltsame Veränderungen an den Nabelschnurgefäßen. Arch. Gynäk. 165, 58, 1937.Google Scholar
  111. Schatz, F.: Die Gefäßverbindungen der Placentakreisläufe eineiiger Zwillinge, ihre Entwicklung und ihre Folgen. Arch. Gynäk. 60, 81, 1900. (also 55, 485, 1898).Google Scholar
  112. Schmidt, H. R.: Pathologie der Decidua, der Eihäute und der Nabelschnur, in: Halban– Seitz, Biologie und Pathologie des Weibes. Vol. 6, 1925.Google Scholar
  113. Schreier, R. & S. Brown: Hematoma of the umbilical cord. Report of a case. Obstet. Gynec. 20, 798, 1962.PubMedGoogle Scholar
  114. Schroyer, W. W.: Single umbilical artery: A search for associated renal agenesis, personal communication 1964, in press.Google Scholar
  115. Schultze, O.: Grundriß der Entwicklungsgeschichte des Menschen und der Säugethiere. p. 110, 156. W. Engelmann, Leipzig 1897.Google Scholar
  116. Scipiades, E. & E. Burg: Über die Morphologie der menschlichen Placenta mit besonderer Rücksicht auf unsere eigenen Studien. Arch. Gynäk. 141, 577, 1930.Google Scholar
  117. Seitz, L.: Pathologisches Verhalten der Plazenta, der Eihäute, der Nabelschnur und des Fetus. In W. Stoeckel: Lehrbuch der Geburtshilfe. G. Fischer, Jena 1945.Google Scholar
  118. Shordania, I.: Der architektonische Aufbau der Gefäße der menschlichen Nachgeburt und ihre Beziehungen zur Entwicklung der Frucht. Arch. Gynäk. 135,168 & 568,1929.Google Scholar
  119. Siddall, R. S.: Chorioangiofibroma (chorioangioma). Amer. J. Obstet. Gynec. 8, 430 & 554, 1924.Google Scholar
  120. Smart, P. J. G.: Some observations on the vascular morphology of the foetal side of the human placenta. J. Obstet. Gynaec. Brit. Comm. 69, 929, 1962.PubMedGoogle Scholar
  121. Soma, H.: Correlation between umbilical vascular anomaly and fetal abnormalities. J. Jap. Obstet. Gynec. Soc. 15, 1050, 1963.Google Scholar
  122. Sundberg, R. D., F. E. Schaar, M. J. S. Powell & D. Denboer: Tissue mast cells in human umbilical cord, and the anticoagulant activity of dried extracts of cords and placentae. Anat. Ree. 118, 35, 1954.Google Scholar
  123. Szécsi, K.: Beiträge zur spontanen Zerreißung der zu kurzen Nabelschnur. Zbl. Gynäk. 77, 1024, 1955.Google Scholar
  124. Thomas, J.: Die gestörte Vaskularisation der menschlichen Plazenta und ihre Auswirkungen auf die Frucht. Geburtsh. Frauenheilk. 19, 801, 1959.PubMedGoogle Scholar
  125. — Untersuchimgsergebnisse über die Aplasie einer Nabelarterie unter besonderer Berücksichtigung der Zwillingsschwangerschaft. Geburtsh. Frauenheilk. 21, 984, 1961.PubMedGoogle Scholar
  126. — Ursprungs- und Aussprossungs- Anomalien der Bauchstielgefäße und ihre Beziehungen zur Frucht und Placenta, p. 2007 in: Scritti in onore del Prof. Giuseppe Tesauro nel XXV anno del Suo insegnamento. Montiano, Napoli, Italy 1962 (A).Google Scholar
  127. — Die Entwicklung von Fetus und Placenta bei Nabelgefäßanomalien. Arch. Gynäk. 198, 216, 1963 (B).Google Scholar
  128. — & M. Schweigert: Zur Aplasie einer Nabelschnurarterie. Geburtsh. Frauenh. 16, 1031, 1956.PubMedGoogle Scholar
  129. Thomsen, K.: Zur Morphologie und Genese der sog. Placentarinfarkte. Arch. Gynäk. 185, 221, 1954; (also 189, 1956), quoted by Becker.Google Scholar
  130. Towell, M. E.: Dizygotic anencephalic twins (Microcephaly, craniorhachischisis). J. Obstet. Gynaec. Brit. Comm. 68, 304, 1961.Google Scholar
  131. Uchida, I. A., J. M. Bowman & H. C. Wang: The 18-trisomy syndrome. New Engl. J. Med. 266, 1198, 1962.Google Scholar
  132. Wahl, F. A.: Hochgradige Torsion der Nabelschnur. Zbl. Gynäk. 53, 783, 1929. Quoted by Scipiades & Burg.Google Scholar
  133. Walker, C. W. & B. G. Pye: The length of the human umbilical cord; a statistical report. Brit. Med. J. i, 546, 1960.Google Scholar
  134. Walz, W.: Über das Ödem der Nabelschnur. Zbl. Gynäk. 69, 144, 1947.Google Scholar
  135. Weber, J.: Constriction of the umbilical cord as a cause of foetal death. Acta Obstet. Gynec. Scand. 42, 259, 1963.PubMedGoogle Scholar
  136. Werthemann, A.: Allgemeine Einführung und Mißbildungen aus placentarer Beeinträchtigung inbesonderheit sog. amniogene Schnürungen und Schädigungen durch die Nabelschnur. Bull. Schweiz. Akad. Med. Wiss. 20, 313, 1964.PubMedGoogle Scholar
  137. Willis, R. A.: The Borderland of Embryology and Pathology. Butterworth, London 1958.Google Scholar
  138. Zimmermann, K.: Intrauteriner Fruchttod infolge Nabelschnurkompression durch Amnionstrang. Zbl. Gynäk. 86, 902, 1964.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • Kurt Benirschke
    • 1
  • Shirley G. Driscoll
    • 2
    • 3
  1. 1.Department of Obstetrics and Gynecology, School of MedicineUniversity of CaliforniaUSA
  2. 2.Boston Lying - In HospitalBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA

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