Hemolytic disease of the newborn

  • Kurt Benirschke
  • Shirley G. Driscoll


In the pathologic states, collectively known as “hemolytic disease of the newborn”, the placenta is an integral component of the reacting system, and often reflects injury shared with the fetus. Hellman and Hertig described the salient features of placentas associated with the hydropic and icteric forms of this disease. Later authors reiterated their observations and pointed out certain features suggestive of pathogenesis (King, Schmidt, Potter, Alvarez, et al.). Just as Hellman and Hertig remarked on the morphologic similarities between these placentas and those associated with congenital syphilis, others have commented on resemblances to less common fetoplacental diseases, which may mimic erythroblastosis fetalis as the latter affects both the fetus and the placenta (Morison, Scott, Burstein et al., Hirszfeld et al., Eng, Callahan, Bain, Hall, Esch, Schubert, Kouvalainen et al., Dussart).


Maternal Blood Chorionic Villus Maternal Circulation Hydatidiform Mole Congenital Toxoplasmosis 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • Kurt Benirschke
    • 1
  • Shirley G. Driscoll
    • 2
    • 3
  1. 1.Department of Obstetrics and Gynecology, School of MedicineUniversity of CaliforniaUSA
  2. 2.Boston Lying - In HospitalBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA

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