Heterogeneity of Gut Glucagon-Like Immunoreactivity (GLI)
One component of gut glucagon-like immunoreactivity (GLI-1) has been purified and characterized. It is proposed that gut GLIs of a given species contain the full homologous glucagon sequence and are immunologically related to the glucagon precursors found in pancreatic A cells. The essential difference between the gastrointestinal cells which produce GLIs and the pancreatic A cells is the degree to which these cells shorten a common primary gene product before storage and secretion.
KeywordsCellulose Albumin Bromide Fractionation Polyacrylamide
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- 5.Jacobsen, H., Demandt, A., Moody, A. J. and Sundby, F. (1976). Europ. J. Biochem. Submitted for publication.Google Scholar
- Moody, A. J., Frandsen, E. K., and Sundby, F. (1975): Fractionation of gut glucagon-like activities by isoelectric focusing in polyacrylamide gel. In: Progress in Isoelectric Focusing and Isotachophoresis. P. G. Righetti, Ed. North-Holland Publishing Co., pp. 179–191.Google Scholar