Abstract

Messenger RNA has the central role in gene expression of conveying the information for making polypeptides from DNA (or, in some cases, RNA) to the ribosomes. Although the concept of mRNA as the direct template for polypeptide synthesis came to be widely accepted following the proposals of Jacob and Monod (1961), it is only in recent years that mRNA has become a well-defined biochemical entity. A number of individual cellular mRNAs have now been substantially purified and shown to direct the synthesis of the expected polypeptides in cell-free systems; nucleotide sequence analysis of one phage RNA that functions as a messenger has been carried to completion, and a good start has been made in dissecting the structure of cellular mRNAs. Whereas a messenger was once pictured simply as a string of nucleotides containing the triplet codons for aminoacyl-tRNAs, we now realize that many mRNAs contain significant amounts of untranslated nucleotide sequences, that ribosomes (and probably some proteins) recognize specific attachment sites in mRNAs, that mRNAs have elements of secondary and tertiary structure, and that many mRNAs are modified after transcription in novel ways.

Keywords

Cellulose Lignin Electrophoresis Sarcoma Myeloma 

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