Experimental middle cerebral artery microsurgical embolectomy

  • M. Dujovny
  • P. J. Barrioneuvo
  • R. K. Laha
  • C. P. Osgood
  • S. DeCastro
  • J. Maroon
  • R. Hellstrom


Acute arterial embolism continues to be a major cause of stroke morbidity in adults.(3) This is particularly true of those patients with certain cardiac disorders such as rheumatic valvular disease, atrial fibrillation, valvular prosthesis, or myocardial infarction. Extracranial carotid artery atheromatous disease is also a major source of cerebral embolic stroke. It is well known that most cerebral embolizations occur in the area of the middle cerebral artery (MCA). Many patients are hospitalized when such episodes occur, and probably could be vigorously treated fairly rapidly. Potential therapy modalities include hypothermia, pressor agents, corticoids, barbiturates, and microsurgical embolectomy or revascularization. Presently, however, there are no clinical or experimental guidelines as to their use and timing. (14,15,16,19)


Middle Cerebral Artery Cerebral Edema Proximal Middle Cerebral Artery Canine Brain Rheumatic Valvular Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ashwood-Smith MJ: Radioprotective and cryoprotective properties of dimethylsulfoxide in cellular systems. Ann NY Acad Sci 141: 45, 1967PubMedCrossRefGoogle Scholar
  2. 2.
    Bauer R, Tellez H: Dexamethasone as treatment in cerebrovascular disease. A controlled study in acute cerebral infarction. Stroke 4: 547, 1973PubMedCrossRefGoogle Scholar
  3. 3.
    Dalai PM, Shah PM, Aiyar RR: Arteriographic study of cerebral embolism. Lancet 2: 358, 1965CrossRefGoogle Scholar
  4. 4.
    De Latorre JC, Kawanaga HM, Hill PK, Cvockard HA, Surgeon JW, Mullen S: Experimental therapy after middle cerebral artery occlusion in monkeys. Surg Forum 26: 489, 1975Google Scholar
  5. 5.
    De Latorre JC, Wowed DW, Kawanaga HM, Mullan S: Dimethyl sulfoxide in the treatment of experimental brain compression. J Neurosurg 38: 345, 1973CrossRefGoogle Scholar
  6. 6.
    Donley RF, Sundt TM Jr: The effect of dexamethasone on the edema of focal cerebral ischemia. Stroke 4: 148, 1973PubMedCrossRefGoogle Scholar
  7. 7.
    Finney JW, Urschel HC, Balla GA: Protection of the ischemic heart with DMSO alone or DMSO with hydrogen peroxide. Ann NY Acad Sci 141: 231, 1967.PubMedCrossRefGoogle Scholar
  8. 8.
    Galicich JH, French LA, Melby JC: Use of dexamethasone in treatment of cerebral edema associated with brain tumors. Lancet 81: 46, 1961Google Scholar
  9. 9.
    Gorog P, Kovacs JB: Effect of dimethyl sulfoxide (DMSO) on various experimental inflammations. Curr Ther Res 10: 486, 1968PubMedGoogle Scholar
  10. 10.
    Harrison MJG, Ross RW: Effect of dexamethasone on experimental cerebral infarction in the gerbil. J Neurol Neurosurg Psychiatry 35: 520, 1972PubMedCrossRefGoogle Scholar
  11. 11.
    Lee, MC, Mastri AR, Waltz AG, and Loewenson RB: Ineffectiveness of dexamethasone for treatment of experimental cerebral infarction. Stroke 5: 216, 1974PubMedCrossRefGoogle Scholar
  12. 12.
    Molinari GF: Experimental cerebral infarction. II. Clinicopathological model of deep cerebral infarction. Stroke 1: 232, 1970PubMedCrossRefGoogle Scholar
  13. 13.
    Pappius HM, McCann WP: Effects of steroids on cerebral edema in cats. Arch Neurol 20: 207, 1969PubMedGoogle Scholar
  14. 14.
    Patten BM, Mendell J, Bruun B, Curtin W, Carter S: Double-blind study of the effects of dexamethasone on acute stroke. Neurology 22: 377, 1972.PubMedGoogle Scholar
  15. 15.
    Smith AL, Hoff JT, Nielsen SL, Larson CP: Barbiturate protection in acute cerebral ischemia. Stroke 5: 1, 1974PubMedCrossRefGoogle Scholar
  16. 16.
    Soloway M, Nadel W, Abbin MS, White RJ: The effect of hyperventilation on subsequent cerebral infarction. Anesthesiology 29: 975, 1968PubMedCrossRefGoogle Scholar
  17. 17.
    Van der Meer C, Valkenburg PW, Remmelts M: Experiments on the radioprotective action of dimethyl sulfoxide. Int J Radiat Biol 6: 151, 1963PubMedCrossRefGoogle Scholar
  18. 18.
    Weissman G, Sessa G, Bevans V: Effect of DMSO on the stabilization of lysosomes by cortisone and chloroquine in vitro. Ann NY Acad Sci 141: 326, 1967CrossRefGoogle Scholar
  19. 19.
    Yasargil MG: Microsurgical approach to the cerebrovascular diseases. In Fusek I, Kunc Z (eds): Present Limits of Neurosurgery. Amsterdam, Excerpta Medica, Avidenum, 1972, pp 357–361Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1977

Authors and Affiliations

  • M. Dujovny
  • P. J. Barrioneuvo
  • R. K. Laha
  • C. P. Osgood
  • S. DeCastro
  • J. Maroon
  • R. Hellstrom

There are no affiliations available

Personalised recommendations