Current Studies on the Proliferation of Cells of the Mononuclear Phagocyte System
During the last decade, there have been many studies on the origin and kinetics of mononuclear phagocytes and the regulation of their production. These studies have led to the postulation of the mononuclear phagocyte system (MPS) (Figure 8–1) (7). By definition, a system is made up of cells with the same origin, morphology, and function (1). Since the reticuloendothelial system (1) includes a number of cell types—reticulum cells, endothelial cells, dendritic cells, and macrophages—that do not fulfill these criteria, it cannot be considered a true system and it should not be designated as such in medico-biological terminology. This chapter, in which recent studies on the proliferation and kinetics of mononuclear phagocytes are briefly reviewed, also presents evidence that supports the existence of a separate mononuclear phagocyte cell line.
KeywordsMononuclear Phagocyte Mononuclear Phagocyte System Humoral Regulation Acute Inflammatory Reaction Normal Steady State
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