The Role of Cyclophosphamide and Total-body Irradiation in Marrow Transplantation for Severe Aplastic Anemia

  • Robert Peter Gale
Conference paper
Part of the Experimental Hematology Today book series (HEMATOLOGY, volume 1978)


Graft failure is a major obstacle to successful bone marrow transplantation in aplastic anemia with an incidence of 30 to 40 percent in several large series (1,3,14,17,21). Graft failure, i.e., either initial failure of engraftment or engraftment with the subsequent breakdown of the graft, is thought to be immunologically mediated and related to graft rejection in most instances.


Aplastic Anemia Graft Failure Graft Rejection Total Body Irradiation Interstitial Pneumonitis 
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Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Robert Peter Gale
    • 1
  1. 1.UCLA Bone Marrow Transplant TeamUSA

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