The Interaction of Anesthetic Agents with Hepatic Microsomal Enzymes

  • James M. Perel
  • Lester C. Mark


Did it ever occur to you that a single dose of any drug would last a lifetime if the body did not have means of handling it? Fortunately, a variety of mechanisms is available to counter any invasion of the body by drugs or other foreign substances. These include distribution to and localization in body tissues, such as storage of unchanged drugs in adipose tissue and elsewhere (a temporizing measure, deferring but not avoiding the need for ultimate disposition), biotransformation mediated by enzymes located prim­arily but not exclusively in liver microsomes, and excretion where appropriate via the kidneys, biliary tract, lungs, skin, and various secretory glands and organs.


Drug Metabolism Liver Microsome Anesthetic Agent Chloral Hydrate Enzyme Induction 
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© Springer-Verlag New York Inc. 1978

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  • James M. Perel
  • Lester C. Mark

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