Review of the Structural Studies on Bleomycin

  • Tomahisa Takita

Abstract

More than 12 years have passed since we started our structural study of bleomycin (BLM). These studies are summarized in this chapter. BLM was isolated as a mixture of more than 10 components from the culture filtrate of Streptomyces verticillus. These were separated by CM-Sephadex column chromatography(1) and found to be different from one another in their terminal amine moieties(2). BLMs thus isolated were blue-colored equimolar copper complexes. BLM has not yet been crystallized, so that we could not utilize X-ray crystallographic analysis. In the initial stages of our structural studies, we used exclusively metal-free BLM A2, the main component of the natural BLMs. Metal-free BLM was prepared by treatment of the copper complex with hydrogen sulfide in methanolic solution.

Keywords

Sulfide Amide Alanine Streptomyces Pyrimidine 

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Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • Tomahisa Takita

There are no affiliations available

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