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Cytotoxicity of Various Bleomycins to Cultured Mammalian Cells

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Bleomycin: Chemical, Biochemical, and Biological Aspects

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Abstract

The successful use of bleomycins as chemotherapeutic agents appears to be dependent upon their metal-binding capacities, but the area of influence, whether metal binding affects their in vivo distribution, stability, and/or activity, is as yet unclear. Much work has been done in the field of nuclear medicine to determine the utility of metal-bleomycin complexes, incorporating radioactive metals as tumor-visualizing agents. From this work it has been found that bleomycin can affect the in vivo distribution of a metal, that the excretion of the metal complexes appears to be similar to the metal-free bleomycin, and that the individual metals form complexes with bleomycin of widely differing stabilities. Of the metal complexes investigated the cobalt complex has been found to have the highest stability and the greatest activity for the tumor tissue (when measured as the concentration of radioactive cobalt). Unfortunately for nuclear medicine the physical characteristics of the best available cobalt radionuclide, cobalt-57, are not ideal for use as a tumor-imaging radionuclide.

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References

  1. H. Suzuki, K. Nagai, H. Yamaki, N. Tanaka, and H. Umezawa, J. Antibiot. (Tokyo), 22, 446 (1969).

    CAS  Google Scholar 

  2. I. Shirakawa, M. Azegami, S.-I. Ishii, and H. Umezawa, J. Antibiot. (Tokyo), 24, 761 (1971).

    CAS  Google Scholar 

  3. E.A Sausville, J. Peisach, and S.B. Horwitz, Biochem. Biophys. Res. Commun., 73, 814 (1976).

    Article  PubMed  CAS  Google Scholar 

  4. J.W. Lawn and S.-K. Sim, Biochem. Biophys. Res. Commun., 77, 1151 (1977).

    Google Scholar 

  5. K. Nagai, H. Suzuki, N. Tanaka, and H. Umezawa, J. Antibiot. (Tokyo), 22, 624 (1969).

    CAS  Google Scholar 

  6. R. Ishida and T. Takahashi, Biochem. Biophys. Res. Commun., 66, 1432 (1975).

    Article  PubMed  CAS  Google Scholar 

  7. K. Nagai, H. Yamaki, H. Suzuki, N. Tanaka, and H. Umezawa, Biochim. Biophys. Acta, 179, 165 (1969).

    PubMed  CAS  Google Scholar 

  8. W.E.G. Müller, Z.I. Yamazaki, H.-J. Breter, and R.K. Zahn, Eur. J. Biochem., 31, 578 (1972).

    Article  Google Scholar 

  9. A.D. Nunn, J. Antibiot. (Tokyo), 29, 1102 (1976).

    CAS  Google Scholar 

  10. A.W. Preece, P.A. Light, P.A. Evans, and A.D. Nunn, Lancet, 953 (1977).

    Google Scholar 

  11. A.D. Nunn, Int. J. Nucl. Med. Biol., 4, 204 (1977).

    Article  PubMed  CAS  Google Scholar 

  12. A.D. Nunn, Eur. J. Nucl. Med., 2, 53 (1977).

    Article  CAS  Google Scholar 

  13. M.R. Zalutsky, A.M. Freidman, J.C. Sullivan, S.L. Ruby, and G.V.S. Rayudu, Int. J. Nucl. Med. Biol., 4, 216 (1977).

    Article  PubMed  CAS  Google Scholar 

  14. B. Rydberg, Radiat. Res., 61, 274 (1975).

    Article  PubMed  CAS  Google Scholar 

  15. A. D. Nunn and J. Lunec, Eur. J. Cancer, 14, 857 (1978).

    Article  PubMed  CAS  Google Scholar 

  16. A. Kana, M. Kojima, and T. Maeda, Jap. J. Clint Radiol., 18, 195 (1973).

    Google Scholar 

  17. A. Kono, Chem. Pharm. Bull. (Tokyo), 25, 2882 (1977).

    CAS  Google Scholar 

  18. K. Takahashi, O. Yoshioka, A. Matsuda, and H. Umezawa, J. Antibiot. (Tokyo), 30, 861 (1977).

    CAS  Google Scholar 

  19. T. Terasima. Y. Takabe, M. Watanabe, T. Katsumata, Prog. Biochem. Pharmacol., 11, 68 (1976).

    PubMed  CAS  Google Scholar 

  20. S.C. Barranco and R.M. Humphrey, Prog. Biochem. Pharmacol., 11, 78 (1976).

    PubMed  CAS  Google Scholar 

  21. C.A. Owen, Jr., Am. J. Physiol., 207, 446 (1964).

    PubMed  CAS  Google Scholar 

  22. C.F. Tessemer, M. Hrgovcic, B.W. Brown, J. Wilbur, and F.B. Thomas, Cancer, 29, 173 (1972).

    Article  Google Scholar 

  23. C. Reynaud, D. Comar, M. Dutheil, P. Blanchiou, O. Monad, R. Parrot, and M. Rymer, J. Nucl. Med., 14, 947 (1973).

    Google Scholar 

  24. J.R.& Baker, R.W. Fleishmann, G.R. Thompson, U. Schaeppi, V. Ilievska, D.A. Cooney, and R.D. Davis, Toxicol. Appl. Pharmacol., 25, 190 (1973).

    Article  PubMed  CAS  Google Scholar 

  25. J-Y. Le Tinier, J. Burnichou, J-M. Garnier, and J. Pre, Nouv. Presse. Med., 5, 649 (1976).

    Google Scholar 

  26. R.L. Willson, In Iron Metabolism, p. 331. CIBA Foundation, Symposium 51, Elsevier, Amsterdam (1977).

    Google Scholar 

  27. R.L. Willson, Chem. Ind. (London), 183 (1977).

    Google Scholar 

  28. J.M. McCord and E.D. Day, Jr., FEBS Lett., 86, 139 (1978).

    Article  PubMed  CAS  Google Scholar 

  29. L.R. deAlvarez, K. Goda, and T. Kimura, Biochem. Biophys. Res. Commun., 69, 687 (1976).

    Article  Google Scholar 

  30. J.J. Van Hemmen and W.J.A. Meuling, Arch. Biochem. Biophys., 182, 743 (1977).

    Article  PubMed  Google Scholar 

  31. L. Roizin-Towle and E.J. Hall, Br. J. Cancer, 37, 254 (1978).

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Adrian D Nunn
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  2. John Lunec
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Mass., 02139, USA

    Sidney M. Hect

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© 1979 Springer-Verlag New York Inc.

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Nunn, A.D., Lunec, J. (1979). Cytotoxicity of Various Bleomycins to Cultured Mammalian Cells. In: Hect, S.M. (eds) Bleomycin: Chemical, Biochemical, and Biological Aspects. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6191-9_21

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  • DOI: https://doi.org/10.1007/978-1-4612-6191-9_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6193-3

  • Online ISBN: 978-1-4612-6191-9

  • eBook Packages: Springer Book Archive

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