Advertisement

The Action of Bleomycin on DNA

  • Franklin Hutchinson
  • Lawrence F. Povirk

Abstract

First, this chapter summarizes our experimental results on the lesions produced by the antitumor drug, bleomycin, on DNA in solution. These results are compared critically with those reported in the literature in an attempt to assess the state of current knowledge in this area.

Keywords

Strand Breakage polA Mutant Bleomycin Treatment Apurinic Site Bleomycin Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H. Suzuki, K. Nagai, E. Akutsu, H. Yamaki, N. Tanaka, and H. Umezawa, J. Antibiot. (Tokyo), 23, 473 (1970).Google Scholar
  2. 2.
    H. Umezawa, H. Asakura, K. Oda, S. Hori, and M. Hori, J. Antibiot. (Tokyo), 26, 521 (1973).Google Scholar
  3. 3.
    T. Onishi, H. Iwata, and Y. Takagi, J. Biochem. (Japan), 77, 745 (1975).Google Scholar
  4. 4.
    E.A. Sausville, J. Peisach, and S.B. Horwitz, Biochem. Biophys. Res. Commun., 73, 814 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    M.J. Sleigh, Nucleic Acid Res., 3, 891 (1976).PubMedGoogle Scholar
  6. 6.
    J. Marmur. J. Mol. Biol., 3, 208 (1961).CrossRefGoogle Scholar
  7. 7.
    L.F. Povirk, W. Kohnlein, and F. Hutchinson, Biochim. Biophys. Acta, 521, 126 (1978).PubMedGoogle Scholar
  8. 8.
    W.E.G. Müller, Z. Yamazaki, H.-J. Breter, and R.K. Zahn, Eur. J. Biochem., 31, 518 (1972).PubMedCrossRefGoogle Scholar
  9. 9.
    C.W. Haidle, K.K. Weiss, and M.T. Kuo, Mol. Pharmacol., 8, 531 (1972).PubMedGoogle Scholar
  10. 10.
    M. Takeshita, A.P. Grollman, and S.B. Horwitz, Virology, 69, 453 (1976).PubMedCrossRefGoogle Scholar
  11. 11.
    C.W. Haidle, M.T. Kuo, and K.K. Weiss, Biochem. Pharmacol., 21, 3308 (1972).Google Scholar
  12. 12.
    R. Ishida and T. Takahashi, Biochem. Biophys. Res. Commun., 66, 1432 (1975).PubMedCrossRefGoogle Scholar
  13. 13.
    W.E.G. Müller, H.J. Rohde, and R.K. Zahn, J. Mol. Med., 1, 173 (1976).Google Scholar
  14. 14.
    I. Shirakawa, M. Azengami, S.-I. Isihi, and H. Umezawa, J. Antibiot. (Tokyo), 24, 761 (1971).Google Scholar
  15. 15.
    L.F. Povirk, W. Wübker, W. Kohnlein, and F. Hutchinson, Nucleic Acids Res., 4, 3573 (1977).PubMedCrossRefGoogle Scholar
  16. 16.
    S.L. Ross and R.E. Moses, Biochemistry, 17, 581 (1978).PubMedCrossRefGoogle Scholar
  17. 17.
    R.S. Lloyd, C.W. Haidle, and D.L. Robberson, Biochemistry, 17, 1890 (1978).PubMedCrossRefGoogle Scholar
  18. 18.
    M.T. Kuo and C.W. Haidle, Biochim. Biophys. Acta, 335, 109 (1974).Google Scholar
  19. 19.
    R. Schyns, M. Mulquet, and W.G. Verly, FEBS Lett., 93, 47 (1978).PubMedCrossRefGoogle Scholar
  20. 20.
    C.R. Bayley, K.W. Brammer, and A.S. Jones, J. Chem. Soc., 1903 (1961).Google Scholar
  21. 21.
    T. Lindahl and A. Andersson, Biochemistry, 11, 3618 (1972).PubMedCrossRefGoogle Scholar
  22. 22.
    C.W. Haidle, Mol. Pharmacol., 7, 645 (1971).PubMedGoogle Scholar
  23. 23.
    L.F. Povirk, M. Hogan, and N. Dattagupta, Biochemistry, 18, 96 (1979).PubMedCrossRefGoogle Scholar
  24. 24.
    M. Chien, A.P. Grouman, and S.B. Horwitz, Biochemistry, 16, 3641 (1977).CrossRefGoogle Scholar
  25. 25.
    H. Murakami, H. Mori, and S. Taira, J. Theoret. Biol., 42, 443 (1973).CrossRefGoogle Scholar
  26. 26.
    J.C. Wang, J. Mol. Biol., 89, 783 (1974).PubMedCrossRefGoogle Scholar
  27. 27.
    M. Waring, J. Mol. Biol., 54, 247 (1970).PubMedCrossRefGoogle Scholar
  28. 28.
    M. Hogan, N. Dattagupta, and D.M. Crothers, Proc. Nat. A cad. Sci. USA, 75, 195 (1978).CrossRefGoogle Scholar
  29. 29.
    H. Umezawa, M. Ishizuka, and T. Takeuchi, Cancer, 20, 891 (1967).PubMedCrossRefGoogle Scholar
  30. 30.
    K. Ohama and T. Kadotani, Japan J. Human Genet., 14, 293 (1970).Google Scholar
  31. 31.
    R.S. Bornstein, D.A. Hungerford, G. Haller, P.F. Engstrom, and J.W. Yarbro, Cancer Res., 31, 2004 (1971).PubMedGoogle Scholar
  32. 32.
    T. Onishi, K. Shimada, and Y. Takagi, Biochim. Biophys. Acta, 312, 238 (1973).Google Scholar
  33. 33.
    H. Suzuki, K. Nagai, H. Yamaki, N. Tanaka, and H. Umezawa, J. Antibiot.(Tokyo), 21, 379 (1968).Google Scholar
  34. 34.
    M. Miyaki, T. Kitayama, and T. Ono, J. Antibiot. (Tokyo), 27, 647 (1974).Google Scholar
  35. 35.
    H. Aoki and H. Sakai, J. Antibiot. (Tokyo), 22, 87 (1967).Google Scholar
  36. 36.
    C.W. Haidle, K.K. Weiss, and M.L. Mace, Biochem. Biophys. Res. Commun., 48, 1179 (1972).PubMedCrossRefGoogle Scholar
  37. 37.
    L.J. Gudas and A.B. Pardee, J. Mol. Biol., 101, 459 (1976).PubMedCrossRefGoogle Scholar
  38. 38.
    H. Umezawa, Fed. Proc., 33, 2296 (1974).PubMedGoogle Scholar
  39. 39.
    R.E. Moses and S.L. Ross, J. Supramolecular Structure, Supplement 2, Abstract 49 (1978).Google Scholar
  40. 40.
    H. Yamagami, M. Ishizawa, and H. Endo,Gann, 65, 61 (1974).PubMedGoogle Scholar
  41. 41.
    H. Endo, J. Antibiot. (Tokyo), 23, 508 (1970).Google Scholar
  42. 42.
    P.P. Saunders and G.A. Schultz, Biochem. Pharmacol., 21, 1657 (1972).PubMedCrossRefGoogle Scholar
  43. 43.
    H. Nakayama, Mutat. Res., 29, 21 (1975).PubMedCrossRefGoogle Scholar
  44. 44.
    S.S. Cohen and J. I, Cancer Res., 36, 2768 (1976).PubMedGoogle Scholar
  45. 45.
    M.J. Sleigh and G.W. Grigg, Biochem. J., 155, 87 (1976).PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • Franklin Hutchinson
  • Lawrence F. Povirk

There are no affiliations available

Personalised recommendations