The Use of Autologous Bone Marrow Transplantation after High-Dose Cytoreductive Therapy in Various Types of Malignancies in Man

  • Karel Dicke
  • Gary Spitzer
  • Dharmvir Verma
  • Axel Zander
  • Sharon Thomson
  • Kenneth McCredie
  • L. J. Peters
  • L. Vellekoop
Part of the Experimental Hematology Today book series (HEMATOLOGY, volume 1979)


The availability of methods of irradiation and chemical agents to destroy tumor cells has stimulated research in the mechanism and in the kinetics of destruction by such modalities. Extensive experimental data that tumor cell kill follows first-order kinetics—with a given dose of cytotoxic therapy destroying a constant fraction of the tumor cell load and not an absolute number of cells—have been provided by Skipper (31). He demonstrated in the leukemia 1210 model in mice that a reduction of the number of tumor cells from 106 to 105 (1-log kill) increased the life-span by 2 days, whereas a 99.999% reduction (5-log kill) could cause a 10-day prolongation of survival. In this model, cure of the recipient infused with leukemic cells was only possible when the initial tumor cell burden was small (19,30).


Bone Marrow Transplantation Bone Marrow Cell Embryonal Carcinoma Autologous Bone Marrow Autologous Bone Marrow Transplantation 
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Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • Karel Dicke
  • Gary Spitzer
  • Dharmvir Verma
  • Axel Zander
  • Sharon Thomson
  • Kenneth McCredie
  • L. J. Peters
  • L. Vellekoop

There are no affiliations available

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