The Coat Colors of Mice

pp 83-108

Dilute and Leaden, the p-Locus, Ruby-Eye, and Ruby-Eye-2

  • Willys K. SilversAffiliated withDepartment of Human Genetics, School of Medicine, University of Pennsylvania

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Recessive mutations at two loci of the mouse produce coat-color deviants which are phenotypically very similar. One of these mutations, described initially by Murray (1931, 1933), is known as leaden (In; chromosome 1) because when homozygous it transforms the intensely pigmented nonagouti coat color to bluish-grey;1 the other is dilute (d; chromosome 9), originally known, because of its influence on black, as the Maltese or blue dilution gene of the mouse fancy. These determinants produce a similar dilution of brown (Plate 2-E) and yellow pigment, giving the coat an overall “washed-out look” (Searle, 1968a).