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The Quantitative Assessment of the Effect of Antiplatelet Drugs on Thrombosis in Microvascular Anastomoses

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Microsurgery for Cerebral Ischemia

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Abstract

The effect of various antiplatelet drugs on the patency of micro vascular anastomoses in a laboratory model using the rat has been studied. The objectives were threefold: (1) to test the usefulness of micro vascular anastomosis as an animal model of thrombosis, as no entirely satisfactory model exists,1 (2) to develop a quantitative measure of thrombosis with which to compare the ant thrombus activity of the drugs, as considerable controversy exists on the basis of prior model experiments and clinical trials as to their efficacy,2 and (3) to determine if enhanced micro vascular patency was possible using single intravenous bolus injection of the drugs during the anastomosis procedure itself.

Supported by a grant from the Ontario Heart Foundation.

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References

  1. Didisheim, P. Animal models useful in the study of thrombosis and anti-thrombotic agents. Prog Hemost Thromb 1: 165–179, 1972.

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  2. Gallus, A.S., Hirsh, J. Anti-thrombotic drugs: Part II. Drugs 12: 132–157, 1976.

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  3. Rosenbaum, T.J., Sundt, T.M. Thrombus formation and endothelial alterations in microarterial anastomoses. J Neurosurg 47: 430–441, 1977.

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  4. Sundt, T.M., Siekert, R.G., Piepgras, D.G., Sharbrough, F.W., Houser, O.W. Bypass surgery for vascular disease of the carotid system. Mayo Clin Proc 51: 677–692, 1976.

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Authors
  1. G. G. Ferguson
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  2. M. L. Bream
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  3. R. B. Philp
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Editor information

Editors and Affiliations

  1. University of Western Ontario, London, Ontario, Canada

    S. J. Peerless M.D., F.R.C.S.(C) (Professor of Neurosurgery, Chairman) (Professor of Neurosurgery, Chairman)

  2. Division of Neurosurgery, Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada

    S. J. Peerless M.D., F.R.C.S.(C) (Professor of Neurosurgery, Chairman) (Professor of Neurosurgery, Chairman)

  3. Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada

    C. W. McCormick M.D.,F.R.C.P.(C) (Assistant Professor of Neurology) (Assistant Professor of Neurology)

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© 1980 Springer-Verlag New York Inc.

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Ferguson, G.G., Bream, M.L., Philp, R.B. (1980). The Quantitative Assessment of the Effect of Antiplatelet Drugs on Thrombosis in Microvascular Anastomoses. In: Peerless, S.J., McCormick, C.W. (eds) Microsurgery for Cerebral Ischemia. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6090-5_37

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  • DOI: https://doi.org/10.1007/978-1-4612-6090-5_37

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6092-9

  • Online ISBN: 978-1-4612-6090-5

  • eBook Packages: Springer Book Archive

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