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Endothelial Dysfunction and the Pathogenesis of Atherosclerosis

  • Michael A. GimbroneJr

Abstract

Vascular endothelium is a structurally simple but functionally complex tissue, the integrity of which is essential to the health of the arterial wall. Since the classical theories of Rokitansky and Virchow, various roles have been ascribed to endothelium in the atherosclerotic process, but only recently have many relevant aspects of its biology been appreciated. In part this is due to the development of new experimental tools, but more importantly it reflects a renewed interest in the functional capabilities of vascular cells, their mutual interactions, and the potential consequences of their dysfunction.

Keywords

Human Vascular Endothelial Cell Prostaglandin Endoperoxide Bovine Endothelial Cell Aortic Endothelium Medial Smooth Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York Inc. 1980

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  • Michael A. GimbroneJr

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